Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

I. Takacs, D. L. Koller, M. Peacock, J. C. Christian, W. E. Evans, S. L. Hui, P. M. Conneally, C. C. Johnston, T. Foroud, M. J. Econs

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)169-173
Number of pages5
JournalBone
Volume27
Issue number1
DOIs
StatePublished - Jul 1 2000

    Fingerprint

Keywords

  • Bone mineral density
  • Interleukin 6
  • Nonparametric linkage

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Takacs, I., Koller, D. L., Peacock, M., Christian, J. C., Evans, W. E., Hui, S. L., Conneally, P. M., Johnston, C. C., Foroud, T., & Econs, M. J. (2000). Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus. Bone, 27(1), 169-173. https://doi.org/10.1016/S8756-3282(00)00296-9