Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

I. Takacs, D. L. Koller, Munro Peacock, J. C. Christian, W. E. Evans, Siu Hui, P. M. Conneally, C. C. Johnston, Tatiana Foroud, Michael Econs

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)169-173
Number of pages5
JournalBone
Volume27
Issue number1
DOIs
StatePublished - Jul 2000

Fingerprint

Bone Density
Interleukin-6
Osteoporosis
Genes
Alleles
Research Personnel
3' Untranslated Regions
African Americans
Population
Hip
Spine
Bone and Bones

Keywords

  • Bone mineral density
  • Interleukin 6
  • Nonparametric linkage

ASJC Scopus subject areas

  • Physiology
  • Hematology

Cite this

Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus. / Takacs, I.; Koller, D. L.; Peacock, Munro; Christian, J. C.; Evans, W. E.; Hui, Siu; Conneally, P. M.; Johnston, C. C.; Foroud, Tatiana; Econs, Michael.

In: Bone, Vol. 27, No. 1, 07.2000, p. 169-173.

Research output: Contribution to journalArticle

Takacs, I. ; Koller, D. L. ; Peacock, Munro ; Christian, J. C. ; Evans, W. E. ; Hui, Siu ; Conneally, P. M. ; Johnston, C. C. ; Foroud, Tatiana ; Econs, Michael. / Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus. In: Bone. 2000 ; Vol. 27, No. 1. pp. 169-173.
@article{034312507a25409fb08c4f09e981aba0,
title = "Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus",
abstract = "A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Bone mineral density, Interleukin 6, Nonparametric linkage",
author = "I. Takacs and Koller, {D. L.} and Munro Peacock and Christian, {J. C.} and Evans, {W. E.} and Siu Hui and Conneally, {P. M.} and Johnston, {C. C.} and Tatiana Foroud and Michael Econs",
year = "2000",
month = "7",
doi = "10.1016/S8756-3282(00)00296-9",
language = "English",
volume = "27",
pages = "169--173",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus

AU - Takacs, I.

AU - Koller, D. L.

AU - Peacock, Munro

AU - Christian, J. C.

AU - Evans, W. E.

AU - Hui, Siu

AU - Conneally, P. M.

AU - Johnston, C. C.

AU - Foroud, Tatiana

AU - Econs, Michael

PY - 2000/7

Y1 - 2000/7

N2 - A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.

AB - A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. Bone mineral density is a complex trait that, presumably, is influenced by multiple genes. Interleukin-6 (IL-6) is an attractive candidate gene for osteoporosis susceptibility, because it has effects on bone cells and has been implicated in the pathogenesis of osteoporosis. Furthermore, previous investigators have identified an association between a 3' UTR polymorphism of the IL-6 gene and BMD. In this study, we searched for linkage and association between this IL-6 gene polymorphism and peak BMD in a large population (812 individuals) of healthy premenopausal sibpairs. Although previous investigators identified only 6 IL-6 alleles, we identified 17 alleles by modifying electrophoretic conditions and evaluating a very large population. We found no evidence for either linkage or association between the IL-6 gene locus and BMD of the spine or hip in either Caucasians or African Americans. Copyright (C) 2000 Elsevier Science Inc.

KW - Bone mineral density

KW - Interleukin 6

KW - Nonparametric linkage

UR - http://www.scopus.com/inward/record.url?scp=0034123164&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034123164&partnerID=8YFLogxK

U2 - 10.1016/S8756-3282(00)00296-9

DO - 10.1016/S8756-3282(00)00296-9

M3 - Article

VL - 27

SP - 169

EP - 173

JO - Bone

JF - Bone

SN - 8756-3282

IS - 1

ER -