Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus

Istvan Takacs, Daniel L. Koller, Munro Peacock, Joe C. Christian, Siu L. Hui, P. Michael Conneally, C. Conrad Johnston, Tatiana Foroud, Michael J. Econs

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Abstract

A major determinant of the risk for osteoporosis in later life is bone mineral density (BMD) attained during early adulthood. BMD is a complex trait that presumably is influenced by multiple genes. Insulin-like growth factor I (IGF-I) is an attractive candidate gene for osteoporosis susceptibility, because IGF-I has marked effects on bone cells and has been implicated in the pathogenesis of osteoporosis. The IGF-I gene contains a microsatellite repeat polymorphism approximately 1 kb upstream from the IGF-I gene transcription start site, and previous investigators have found a higher prevalence of the 192/192 genotype of this polymorphism among men with idiopathic osteoporosis compared to controls. In this study we used this IGF-I polymorphism to test for an association between this polymorphism and BMD in our large population of premenopausal women (1 sister randomly chosen from 292 Caucasian and 71 African-American families). We also used this polymorphism to detect linkage to BMD elsewhere in the IGF-I gene or in a nearby gene using sibling pair linkage analysis in healthy premenopausal sister pairs (542 sibling pairs: 418 Caucasian and 124 African-American). Neither test provided any evidence of linkage or association between the IGF-I gene locus and spine or femoral neck BMD in Caucasians or African Americans.

Original languageEnglish
Pages (from-to)4467-4471
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume84
Issue number12
StatePublished - 1999

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Insulin-Like Growth Factor I
Bone Density
Minerals
Siblings
Bone
Genes
Polymorphism
Osteoporosis
African Americans
Transcription Initiation Site
Femur Neck
Microsatellite Repeats
Spine
Genotype
Research Personnel
Bone and Bones
Population

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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Sibling pair linkage and association studies between bone mineral density and the insulin-like growth factor I gene locus. / Takacs, Istvan; Koller, Daniel L.; Peacock, Munro; Christian, Joe C.; Hui, Siu L.; Conneally, P. Michael; Johnston, C. Conrad; Foroud, Tatiana; Econs, Michael J.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 84, No. 12, 1999, p. 4467-4471.

Research output: Contribution to journalArticle

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AU - Johnston, C. Conrad

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