Sickle cell disease and HIV: A case highlighting management challenges for children in a resource-limited setting

Esther Brenda Odera, Charles Kwobah, Geren Stone, Faraj Some, Rachel Christine Vreeman

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.

Original languageEnglish (US)
Pages (from-to)113-116
Number of pages4
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number2
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • antiretroviral therapy
  • comorbidity
  • HIV
  • sickle cell disease

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

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