Sickle cell disease and HIV: A case highlighting management challenges for children in a resource-limited setting

Esther Brenda Odera, Charles Kwobah, Geren Stone, Faraj Some, Rachel Vreeman

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.

Original languageEnglish
Pages (from-to)113-116
Number of pages4
JournalJournal of the International Association of Providers of AIDS Care
Volume13
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Case Management
Sickle Cell Anemia
HIV
Inborn Genetic Diseases
Anemia
Hypersensitivity
Hemoglobins
Therapeutics
Guidelines
Pediatrics
Mutation
Mortality
Pharmaceutical Preparations
Genes

Keywords

  • antiretroviral therapy
  • comorbidity
  • HIV
  • sickle cell disease

ASJC Scopus subject areas

  • Immunology
  • Dermatology
  • Infectious Diseases

Cite this

Sickle cell disease and HIV : A case highlighting management challenges for children in a resource-limited setting. / Odera, Esther Brenda; Kwobah, Charles; Stone, Geren; Some, Faraj; Vreeman, Rachel.

In: Journal of the International Association of Providers of AIDS Care, Vol. 13, No. 2, 2014, p. 113-116.

Research output: Contribution to journalArticle

Odera, Esther Brenda ; Kwobah, Charles ; Stone, Geren ; Some, Faraj ; Vreeman, Rachel. / Sickle cell disease and HIV : A case highlighting management challenges for children in a resource-limited setting. In: Journal of the International Association of Providers of AIDS Care. 2014 ; Vol. 13, No. 2. pp. 113-116.
@article{34a3fe9ff0004ba79a8eac519c4ec8fb,
title = "Sickle cell disease and HIV: A case highlighting management challenges for children in a resource-limited setting",
abstract = "Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.",
keywords = "antiretroviral therapy, comorbidity, HIV, sickle cell disease",
author = "Odera, {Esther Brenda} and Charles Kwobah and Geren Stone and Faraj Some and Rachel Vreeman",
year = "2014",
doi = "10.1177/2325957413508320",
language = "English",
volume = "13",
pages = "113--116",
journal = "Journal of the International Association of Providers of AIDS Care",
issn = "2325-9574",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - Sickle cell disease and HIV

T2 - A case highlighting management challenges for children in a resource-limited setting

AU - Odera, Esther Brenda

AU - Kwobah, Charles

AU - Stone, Geren

AU - Some, Faraj

AU - Vreeman, Rachel

PY - 2014

Y1 - 2014

N2 - Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.

AB - Sickle cell disease (SCD) is a genetic disorder resulting from a mutation in the hemoglobin (Hb) gene. Sickle cell disease results in chronic anemia and a variety of acute and chronic complications that can lead to early mortality. A child with both SCD and HIV presents a management challenge, particularly in a resource-limited setting. In this case report, we describe the case of an 18-month-old Kenyan girl with SCD and HIV who developed a severe hypersensitivity reaction to first-line antiretroviral therapy (ART). Selecting an appropriate drug substitute for a child with SCD and HIV presents a management dilemma when the available options have problematic side effect profiles or are inaccessible or inappropriate according to national guidelines. The challenges in choosing an appropriate ART regimen for a child with SCD and HIV highlight the lack of data and scarcity of treatment options for pediatric patients.

KW - antiretroviral therapy

KW - comorbidity

KW - HIV

KW - sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=84899553066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899553066&partnerID=8YFLogxK

U2 - 10.1177/2325957413508320

DO - 10.1177/2325957413508320

M3 - Article

C2 - 24257463

AN - SCOPUS:84899553066

VL - 13

SP - 113

EP - 116

JO - Journal of the International Association of Providers of AIDS Care

JF - Journal of the International Association of Providers of AIDS Care

SN - 2325-9574

IS - 2

ER -