Signal transduction in acute myeloid leukemia–Implications for novel therapeutic concepts

Heiko Konig, Cedric Dos Santos

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Acute Myeloid Leukemia (AML) is a highly aggressive clonal hematopoietic disorder that has been managed with largely unchanged treatment protocols for the past decades. Although conventional chemotherapy bears the potential to cure some AML patients, the course of the disease is frequently fatal despite treatment highlighting the need for novel therapeutic concepts. Recent progress in genetic technologies significantly furthered our understanding of the molecular events leading to the disease, but these advances have not yet been successfully translated into improved treatment outcomes. Here, we review some of the new promising targets expressed by leukemic blasts, including important signaling pathways involved in AML stem/progenitor cell maintenance and drug resistance. We furthermore discuss novel targeted therapies in pre-clinical and clinical development thereby focusing on new compounds targeting receptor and non-receptor tyrosine kinases, farnesyltransferase proteins, and epigenetic modifiers.

Original languageEnglish (US)
Pages (from-to)803-821
Number of pages19
JournalCurrent cancer drug targets
Volume15
Issue number9
DOIs
StatePublished - Nov 1 2015

Keywords

  • Acute myeloid leukemia
  • Leukemic stem cells-chemotherapy
  • Signaling pathways

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Drug Discovery
  • Cancer Research

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