Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways

Xiao Ming Yin

Research output: Contribution to journalReview article

251 Scopus citations

Abstract

Two major apoptosis pathways have been defined in mammalian cells, the Fas/TNF-R1 death receptor pathway and the mitochondria pathway. The Bcl-2 family proteins consist of both anti-apoptosis and pro- apoptosis members that regulate apoptosis, mainly by controlling the release of cytochrome c and other mitochondrial apoptotic events. However, death signals mediated by Fas/TNF-R1 receptors can usually activate caspases directly, bypassing the need for mitochondria and escaping the regulation by Bcl-2 family proteins. Bid is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Activated Bid is translocated to mitochondria and induces cytochrome c release, which in turn activates downstream caspases. Such a connection between the two apoptosis pathways could be important for induction of apoptosis in certain types of cells and responsible for the pathogenesis of a number of human diseases.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalCell Research
Volume10
Issue number3
DOIs
StatePublished - Sep 2000

    Fingerprint

Keywords

  • Apoptosis
  • Bcl-2 family proteins
  • Bid
  • Fas
  • TNF

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this