Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis

Nolan J. Hoffman, Jeffrey S. Elmendorf

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A central feature of this process is the coordinated accumulation of the glucose transporter GLUT4 into the plasma membrane. New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are of emerging interest, particularly those at or just beneath the plasma membrane. This review examines signals that functionally engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 itinerary, and appraises the involvement of plasma membrane parameters in GLUT4 control. We also explore how these newly-defined signaling, cytoskeletal and membrane mechanisms could be of therapeutic interest in the treatment and/or prevention of GLUT4 dysregulation in disease.

Original languageEnglish (US)
Pages (from-to)110-116
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number3
DOIs
StatePublished - Mar 1 2011

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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