Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis

Nolan J. Hoffman, Jeffrey Elmendorf

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A central feature of this process is the coordinated accumulation of the glucose transporter GLUT4 into the plasma membrane. New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are of emerging interest, particularly those at or just beneath the plasma membrane. This review examines signals that functionally engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 itinerary, and appraises the involvement of plasma membrane parameters in GLUT4 control. We also explore how these newly-defined signaling, cytoskeletal and membrane mechanisms could be of therapeutic interest in the treatment and/or prevention of GLUT4 dysregulation in disease.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number3
DOIs
StatePublished - Mar 2011

Fingerprint

Exocytosis
Cell Membrane
Membranes
Insulin
Facilitative Glucose Transport Proteins
Adipose Tissue
Skeletal Muscle
Medicine
Glucose
Muscles
Therapeutics

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis. / Hoffman, Nolan J.; Elmendorf, Jeffrey.

In: Trends in Endocrinology and Metabolism, Vol. 22, No. 3, 03.2011, p. 110-116.

Research output: Contribution to journalArticle

@article{1583b84bd7524fb4a64e28de17445bb8,
title = "Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis",
abstract = "Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A central feature of this process is the coordinated accumulation of the glucose transporter GLUT4 into the plasma membrane. New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are of emerging interest, particularly those at or just beneath the plasma membrane. This review examines signals that functionally engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 itinerary, and appraises the involvement of plasma membrane parameters in GLUT4 control. We also explore how these newly-defined signaling, cytoskeletal and membrane mechanisms could be of therapeutic interest in the treatment and/or prevention of GLUT4 dysregulation in disease.",
author = "Hoffman, {Nolan J.} and Jeffrey Elmendorf",
year = "2011",
month = "3",
doi = "10.1016/j.tem.2010.12.001",
language = "English",
volume = "22",
pages = "110--116",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis

AU - Hoffman, Nolan J.

AU - Elmendorf, Jeffrey

PY - 2011/3

Y1 - 2011/3

N2 - Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A central feature of this process is the coordinated accumulation of the glucose transporter GLUT4 into the plasma membrane. New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are of emerging interest, particularly those at or just beneath the plasma membrane. This review examines signals that functionally engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 itinerary, and appraises the involvement of plasma membrane parameters in GLUT4 control. We also explore how these newly-defined signaling, cytoskeletal and membrane mechanisms could be of therapeutic interest in the treatment and/or prevention of GLUT4 dysregulation in disease.

AB - Solving how insulin regulates glucose transport into skeletal muscle and adipose tissue remains a fundamental challenge in biology and a significant issue in medicine. A central feature of this process is the coordinated accumulation of the glucose transporter GLUT4 into the plasma membrane. New signaling and cytoskeletal mechanisms of insulin-stimulated GLUT4 exocytosis are of emerging interest, particularly those at or just beneath the plasma membrane. This review examines signals that functionally engage GLUT4 exocytosis, considers cytoskeletal regulation of the stimulated GLUT4 itinerary, and appraises the involvement of plasma membrane parameters in GLUT4 control. We also explore how these newly-defined signaling, cytoskeletal and membrane mechanisms could be of therapeutic interest in the treatment and/or prevention of GLUT4 dysregulation in disease.

UR - http://www.scopus.com/inward/record.url?scp=79952107840&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952107840&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2010.12.001

DO - 10.1016/j.tem.2010.12.001

M3 - Article

VL - 22

SP - 110

EP - 116

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 3

ER -