Signaling pathways in pancreatic cancer

Meir Preis, Murray Korc

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by a plethora of molecular alterations that include major and minor driving mutations, the presence of intense desmoplasia exhibiting numerous proliferating pancreatic stellate cells (PSC) and cancer-associated fibroblasts that produce fibronectin and collagens, and foci of inflammatory cells that produce mitogenic cytokines. This review will focus on signaling by tyrosine kinase receptors, and the role of transforming growth factor beta in this malignancy is described briefly. Potential for therapeutic interventions will be discussed in relation to specific pathways.

Original languageEnglish (US)
Pages (from-to)115-129
Number of pages15
JournalCritical Reviews in Eukaryotic Gene Expression
Volume21
Issue number2
StatePublished - 2011
Externally publishedYes

Fingerprint

Pancreatic Neoplasms
Pancreatic Stellate Cells
Receptor Protein-Tyrosine Kinases
Fibronectins
Transforming Growth Factor beta
Neoplasms
Adenocarcinoma
Collagen
Cytokines
Mutation
Therapeutics
Cancer-Associated Fibroblasts

Keywords

  • Pancreatic cancer
  • Signaling
  • Tyrosine kinase receptors

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Signaling pathways in pancreatic cancer. / Preis, Meir; Korc, Murray.

In: Critical Reviews in Eukaryotic Gene Expression, Vol. 21, No. 2, 2011, p. 115-129.

Research output: Contribution to journalArticle

Preis, M & Korc, M 2011, 'Signaling pathways in pancreatic cancer', Critical Reviews in Eukaryotic Gene Expression, vol. 21, no. 2, pp. 115-129.
Preis, Meir ; Korc, Murray. / Signaling pathways in pancreatic cancer. In: Critical Reviews in Eukaryotic Gene Expression. 2011 ; Vol. 21, No. 2. pp. 115-129.
@article{1a6673edc5034fbdb5b47c18b59d58e4,
title = "Signaling pathways in pancreatic cancer",
abstract = "Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by a plethora of molecular alterations that include major and minor driving mutations, the presence of intense desmoplasia exhibiting numerous proliferating pancreatic stellate cells (PSC) and cancer-associated fibroblasts that produce fibronectin and collagens, and foci of inflammatory cells that produce mitogenic cytokines. This review will focus on signaling by tyrosine kinase receptors, and the role of transforming growth factor beta in this malignancy is described briefly. Potential for therapeutic interventions will be discussed in relation to specific pathways.",
keywords = "Pancreatic cancer, Signaling, Tyrosine kinase receptors",
author = "Meir Preis and Murray Korc",
year = "2011",
language = "English (US)",
volume = "21",
pages = "115--129",
journal = "Critical Reviews in Eukaryotic Gene Expression",
issn = "1045-4403",
publisher = "Begell House Inc.",
number = "2",

}

TY - JOUR

T1 - Signaling pathways in pancreatic cancer

AU - Preis, Meir

AU - Korc, Murray

PY - 2011

Y1 - 2011

N2 - Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by a plethora of molecular alterations that include major and minor driving mutations, the presence of intense desmoplasia exhibiting numerous proliferating pancreatic stellate cells (PSC) and cancer-associated fibroblasts that produce fibronectin and collagens, and foci of inflammatory cells that produce mitogenic cytokines. This review will focus on signaling by tyrosine kinase receptors, and the role of transforming growth factor beta in this malignancy is described briefly. Potential for therapeutic interventions will be discussed in relation to specific pathways.

AB - Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by a plethora of molecular alterations that include major and minor driving mutations, the presence of intense desmoplasia exhibiting numerous proliferating pancreatic stellate cells (PSC) and cancer-associated fibroblasts that produce fibronectin and collagens, and foci of inflammatory cells that produce mitogenic cytokines. This review will focus on signaling by tyrosine kinase receptors, and the role of transforming growth factor beta in this malignancy is described briefly. Potential for therapeutic interventions will be discussed in relation to specific pathways.

KW - Pancreatic cancer

KW - Signaling

KW - Tyrosine kinase receptors

UR - http://www.scopus.com/inward/record.url?scp=80755163679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80755163679&partnerID=8YFLogxK

M3 - Article

C2 - 22077151

AN - SCOPUS:80755163679

VL - 21

SP - 115

EP - 129

JO - Critical Reviews in Eukaryotic Gene Expression

JF - Critical Reviews in Eukaryotic Gene Expression

SN - 1045-4403

IS - 2

ER -