Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness

Koichi Hashimoto, Barney S. Graham, Mark W. Geraci, Garret A. FitzGerald, Karine Egan, Weisong Zhou, Kasia Goleniewska, Jamye F. O'Neal, Jason D. Morrow, Russell K. Durbin, Peter F. Wright, Robert D. Collins, Tatsuo Suzutani, R. Stokes Peebles

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I2 (PGI2). Mice that overexpress PGI 2 synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to nontransgenic littermates. In contrast, mice deficient in the PGI2 receptor IP have exacerbated RSV-induced weight loss with delayed viral clearance and increased levels of gamma interferon in the lung compared to wild-type mice. These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI2 is a potential therapeutic target in the treatment of RSV.

Original languageEnglish (US)
Pages (from-to)10303-10309
Number of pages7
JournalJournal of Virology
Volume78
Issue number19
DOIs
StatePublished - Oct 2004
Externally publishedYes

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Epoprostenol Receptors
Respiratory Syncytial Viruses
prostaglandins
Respiratory Syncytial Virus Infections
viruses
receptors
Epoprostenol
Interferon-gamma
Weight Loss
mice
interferon-gamma
Lung
weight loss
lungs
Prostaglandins
Antiviral Agents
Epithelium
virus replication
infection
epithelium

ASJC Scopus subject areas

  • Immunology

Cite this

Hashimoto, K., Graham, B. S., Geraci, M. W., FitzGerald, G. A., Egan, K., Zhou, W., ... Peebles, R. S. (2004). Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. Journal of Virology, 78(19), 10303-10309. https://doi.org/10.1128/JVI.78.19.10303-10309.2004

Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. / Hashimoto, Koichi; Graham, Barney S.; Geraci, Mark W.; FitzGerald, Garret A.; Egan, Karine; Zhou, Weisong; Goleniewska, Kasia; O'Neal, Jamye F.; Morrow, Jason D.; Durbin, Russell K.; Wright, Peter F.; Collins, Robert D.; Suzutani, Tatsuo; Peebles, R. Stokes.

In: Journal of Virology, Vol. 78, No. 19, 10.2004, p. 10303-10309.

Research output: Contribution to journalArticle

Hashimoto, K, Graham, BS, Geraci, MW, FitzGerald, GA, Egan, K, Zhou, W, Goleniewska, K, O'Neal, JF, Morrow, JD, Durbin, RK, Wright, PF, Collins, RD, Suzutani, T & Peebles, RS 2004, 'Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness', Journal of Virology, vol. 78, no. 19, pp. 10303-10309. https://doi.org/10.1128/JVI.78.19.10303-10309.2004
Hashimoto, Koichi ; Graham, Barney S. ; Geraci, Mark W. ; FitzGerald, Garret A. ; Egan, Karine ; Zhou, Weisong ; Goleniewska, Kasia ; O'Neal, Jamye F. ; Morrow, Jason D. ; Durbin, Russell K. ; Wright, Peter F. ; Collins, Robert D. ; Suzutani, Tatsuo ; Peebles, R. Stokes. / Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. In: Journal of Virology. 2004 ; Vol. 78, No. 19. pp. 10303-10309.
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