Significance of Programmed Death Ligand 1 (PD-L1) Immunohistochemical Expression in Colorectal Cancer

Lisha Wang, Fei Ren, Qifeng Wang, Lee Ann Baldridge, M. Francesca Monn, Kurt W. Fisher, Weiqi Sheng, Xiaoyan Zhou, Xiang Du, Liang Cheng

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Introduction: The significance of programmed death ligand 1 (PD-L1) expression in the prognosis of patients with colorectal cancer remains to be determined. Methods: We assessed the levels of PD-L1 expression in tumor-infiltrating immune cells as well as tumor cells, and evaluated the association between PD-L1 expression and clinical outcome in 262 colorectal cancer patients. Results: In univariate analysis, TNM stage (p < 0.001), PD-L1 expression in tumor-infiltrating immune cells (p = 0.016), tumor location (p = 0.033), and tumor size (p = 0.019) were associated with survival. In multivariate analysis, PD-L1 expression in tumor infiltrating immune cells and TNM stage were independent prognostic factors (HR 1.83, 95 % CI 1.09–3.05, p = 0.021; HR 2.49, 95 % CI 1.51–4.12, p < 0.001, respectively). Eight percent of patients had positive PD-L1 expression in tumor cells. In contrast, PD-L1 expression in tumor cells was not significantly associated with patient clinical outcome. Conclusions: Our data indicate that PD-L1 status in tumor-infiltrating immune cells is a significant prognostic factor in colorectal cancer patients. There is a need for randomized studies that evaluate the role of PD-L1 expression in colorectal cancer in treatment decision protocols for novel immunotherapy.

Original languageEnglish (US)
Pages (from-to)175-181
Number of pages7
JournalMolecular Diagnosis and Therapy
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2016

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ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

Cite this

Wang, L., Ren, F., Wang, Q., Baldridge, L. A., Monn, M. F., Fisher, K. W., Sheng, W., Zhou, X., Du, X., & Cheng, L. (2016). Significance of Programmed Death Ligand 1 (PD-L1) Immunohistochemical Expression in Colorectal Cancer. Molecular Diagnosis and Therapy, 20(2), 175-181. https://doi.org/10.1007/s40291-016-0188-1