Significant linkage of Parkinson disease to chromosome 2q36-37

Nathan Pankratz, William C. Nichols, Sean K. Uniacke, Cheryl Halter, Alice Rudolph, Cliff Shults, P. Michael Conneally, Tatiana Foroud, Lawrence Golbe, William Koller, Kelly Lyons, Karen Marder, Frederick Marshall, David Oakes, Aileen Shinaman, Eric Siemers, Joanne Wojcieszek, Joann Belden, Julie Carter, Richard CamicioliPamela Andrews, Magali Fernandez, Jean Hubble, Carson Reider, Ali Rajput, Alex Rajput, Theresa Shirley, Michel Panisset, Jean Hall, Tilak Mendis, David A. Grimes, Peggy Gray, Carmen Serrano Ramos, Sandra Roque, Stephen Reich, Becky Dunlop, Robert Hauser, Juan Sanchez-Ramos, Theresa Zesiewicz, Holly Delgado, Joseph Friedman, Hubert Fernandez, Margaret Lannon, Lauren Seeberger, Christopher O'Brien, Deborah Judd, Lawrence Elmer, Kathy Davis, Deborah Fontaine, Ronald Pfeiffer, Brenda Pfeiffer, Michael Aminoff, Mariann DiMinno, Daniel Truong, Mayank Pathak, Anhoa Tran, Robert Rodnitzky, Judith Dobson, Rajesh Pahwa, Stephanie Thomas, Danna Jennings, Kenneth Marek, Susan Mendick, Juliette Harris, William Weiner, Roger Kurlan, Debra Berry, Peter Lewitt, Maryan DeAngelis, Paul Tuite, Robyn Schacherer, Wayne Martin, Marguerite Wieler, Bala Manyam, Patricia Simpson, John Bertoni, Carolyn Peterson, Mark F. Gordon, Joanna Hamann, Joseph Jankovic, Christine Hunter, Stewart Factor, Sharon Evans, Anette Nieves, Julie So, Mark Stacy, Kelli Williamson, Francis Walker, Victoria Hunt, Un Jung Kang, Shirley Uy, Karen Blindauer, Jeannine Petit, David Simon, Lisa Scollins, Rachel Saunders Pullman, Karyn Boyar, Paul Gordon, Joan Werner

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.

Original languageEnglish (US)
Pages (from-to)1053-1057
Number of pages5
JournalAmerican Journal of Human Genetics
Volume72
Issue number4
DOIs
StatePublished - Apr 1 2003

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Pankratz, N., Nichols, W. C., Uniacke, S. K., Halter, C., Rudolph, A., Shults, C., Conneally, P. M., Foroud, T., Golbe, L., Koller, W., Lyons, K., Marder, K., Marshall, F., Oakes, D., Shinaman, A., Siemers, E., Wojcieszek, J., Belden, J., Carter, J., ... Werner, J. (2003). Significant linkage of Parkinson disease to chromosome 2q36-37. American Journal of Human Genetics, 72(4), 1053-1057. https://doi.org/10.1086/374383