Similar verbal fluency patterns in amnestic mild cognitive impairment and alzheimer's disease

Edmond Teng, Judith Leone-Friedman, Grace J. Lee, Woo Stephanie, Liana G. Apostolova, Shelly Harrell, John M. Ringman, Po H. Lu

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Disproportionately greater deficits in semantic relative to phonemic verbal fluency are seen in Alzheimer's disease (AD) and have been attributed to neurodegenerative changes in the temporal lobe. Amnestic (AMN) mild cognitive impairment (MCI), which often represents incipient AD, is also characterized by early temporal lobe neuropathology, but previous comparisons of verbal fluency between AD andAMNMCI have yielded mixed results.We examined semantic and phonemic verbal fluency performance in 399 individuals (78 AD, 138 AMN MCI, 72 nonamnestic MCI, and 111 cognitively normal controls). Similar verbal fluency patterns were seen in AMN MCI and AD; both groups exhibited disproportionately poorer performance on semantic verbal fluency relative to normal controls. However, relative verbal fluency indices performed more poorly than individual semantic or phonemic verbal fluency indices for discriminating AMN MCI or AD participants from normal controls, suggesting that they are unlikely to provide additional utility for predicting progression from MCI to AD.

Original languageEnglish (US)
Pages (from-to)400-410
Number of pages11
JournalArchives of Clinical Neuropsychology
Volume28
Issue number5
DOIs
StatePublished - Aug 2013
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Assessment
  • Cognition
  • Dementia
  • Mild cognitive impairment
  • Verbal fluency

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Psychiatry and Mental health

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    Teng, E., Leone-Friedman, J., Lee, G. J., Stephanie, W., Apostolova, L. G., Harrell, S., Ringman, J. M., & Lu, P. H. (2013). Similar verbal fluency patterns in amnestic mild cognitive impairment and alzheimer's disease. Archives of Clinical Neuropsychology, 28(5), 400-410. https://doi.org/10.1093/arclin/act039