Similarities and differences in semantic and phonological processing with age: Patterns of functional MRI activation

S. C. Johnson, Andrew Saykin, L. A. Flashman, T. W. McAllister, J. R. O'Jile, M. B. Sparling, S. J. Guerin, C. H. Moritz, A. C. Mamourian

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In this investigation, we analyzed the effect of age on fMRI activation during semantic and phonological decision tasks using whole-brain echo-planar imaging. Nine right-handed healthy younger adults were compared to nine right-handed healthy older adult volunteers. While undergoing fMRI scanning, subjects completed three functional MRI auditory stimulation tasks requiring semantic or phonological decisions (match/mismatch) about word pairs (category-exemplar, category-function, pseudo-word). Performance scores on these tasks did not differ between age groups. The fMRI images were motion corrected, spatially normalized, and statistically analyzed for group similarities and differences using a random-effects model. For the semantic tasks, both older and younger adults showed activity within the inferior frontal gyms (left more than right) and left superior temporal gyrus, whereas small regional age differences (younger > older) were found in the left inferior precentral region. For the phonologic task, common areas of activation were found in the superior temporal gyrus (left more than right). Age-related differences in the phonologic task were observed predominantly in the right angular region. The results were not changed by entry of a quantitative atrophy index as a covariate. These findings highlight the similarities in semantic processing across age groups and suggest that global age related atrophy is not impacting activation significantly in healthy older adults.

Original languageEnglish (US)
Pages (from-to)307-320
Number of pages14
JournalAging, Neuropsychology, and Cognition
Volume8
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

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Semantics
Magnetic Resonance Imaging
Temporal Lobe
Atrophy
Young Adult
Age Groups
Echo-Planar Imaging
Acoustic Stimulation
Volunteers
Brain

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology
  • Experimental and Cognitive Psychology

Cite this

Similarities and differences in semantic and phonological processing with age : Patterns of functional MRI activation. / Johnson, S. C.; Saykin, Andrew; Flashman, L. A.; McAllister, T. W.; O'Jile, J. R.; Sparling, M. B.; Guerin, S. J.; Moritz, C. H.; Mamourian, A. C.

In: Aging, Neuropsychology, and Cognition, Vol. 8, No. 4, 2001, p. 307-320.

Research output: Contribution to journalArticle

Johnson, SC, Saykin, A, Flashman, LA, McAllister, TW, O'Jile, JR, Sparling, MB, Guerin, SJ, Moritz, CH & Mamourian, AC 2001, 'Similarities and differences in semantic and phonological processing with age: Patterns of functional MRI activation', Aging, Neuropsychology, and Cognition, vol. 8, no. 4, pp. 307-320. https://doi.org/10.1076/anec.8.4.307.5639
Johnson, S. C. ; Saykin, Andrew ; Flashman, L. A. ; McAllister, T. W. ; O'Jile, J. R. ; Sparling, M. B. ; Guerin, S. J. ; Moritz, C. H. ; Mamourian, A. C. / Similarities and differences in semantic and phonological processing with age : Patterns of functional MRI activation. In: Aging, Neuropsychology, and Cognition. 2001 ; Vol. 8, No. 4. pp. 307-320.
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