The reference standards 4a-b, 6a-b, 7a-c, and desmethylated precursors 9a-b, 10a-b, 8a-c were synthesized from 4-methoxyaniline, ethyl 2-chloro-acetoacetate and substituted benzene-1,2-diamines with 3, 5, 6 steps in 61-67%, 34-41%, 23-31%, and with 4, 6, 7 steps in 49-57%, 28-35%, 20-27% overall chemical yield, respectively. The target tracers [11C]4a-b, [11C]6a-b, [11C]7a-c were synthesized from their corresponding precursors with [11C]CH3OTf through O-[11C]methylation and isolated by simplified SPE in 40-60% decay corrected radiochemical yields at EOB, with 185-370GBq/μmol specific activity at EOS.
- Carbon-11-labeled 1,2,4-triazolo[4,3,a]quinoxalin-1-one derivatives
- Cardiac diseases
- Neurological disorders
- Positron emission tomography (PET)
ASJC Scopus subject areas