Simulation of mechanical environment in active lead fixation: Effect of fixation helix size

Xuefeng Zhao, Jonathan F. Wenk, Mike Burger, Yi Liu, Mithilesh K. Das, William Combs, Liang Ge, Julius M. Guccione, Ghassan S. Kassab

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The risk of myocardial penetration due to active-fixation screw-in type pacing leads has been reported to increase as the helix electrodes become smaller. In order to understand the contributing factors for lead penetration, we conducted finite element analyses of acute myocardial micro-damage induced by a pacemaker lead screw-in helix electrode. We compared the propensity for myocardial micro-damage of seven lead designs including a baseline model, three modified designs with various helix wire cross-sectional diameters, and three modified designs with different helix diameters. The comparisons show that electrodes with a smaller helix wire diameter cause more severe micro-damage to the myocardium in the early stage. The damage severity, represented by the volume of failed elements, is roughly the same in the middle stage, whereas in the later stage the larger helix wire diameter generally causes more severe damage. The onset of myocardial damage is not significantly affected by the helix diameter. As the helix diameter increases, however, the extent of myocardial damage increases accordingly. The present findings identified several of the major risk factors for myocardial damage whose consideration for lead use and design might improve acute and chronic lead performance.

Original languageEnglish (US)
Article number061006
JournalJournal of Biomechanical Engineering
Volume133
Issue number6
DOIs
StatePublished - Jul 19 2011

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Keywords

  • cardiac penetration
  • defibrillation lead
  • finite element analysis
  • pacing lead

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physiology (medical)

Cite this

Zhao, X., Wenk, J. F., Burger, M., Liu, Y., Das, M. K., Combs, W., Ge, L., Guccione, J. M., & Kassab, G. S. (2011). Simulation of mechanical environment in active lead fixation: Effect of fixation helix size. Journal of Biomechanical Engineering, 133(6), [061006]. https://doi.org/10.1115/1.4004288