Simulation of signal recovery in PET studies of cerebral physiology and biochemistry

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Three-dimensional positron emission tomography (PET) simulation procedures based upon a digital brain phantom and tomographic detector response functions have been performed. The recovery of PET signals from anatomical brain structures and subsequent error propagation into both static and kinetic data analysis stratagies have been investigated for the measurement of cerebral blood flow, metabolism, and neurotransmission systems. Errors created by the limitations of the PET tomography in human neurologic studies for both static and dynamic data-acquisition schemes are evaluated based upon the simulation techniques. It is shown that careful attention to the definition of the 3D distribution of radionuclides and the characteristics of PET tomographic systems enable the production of reliable results. Applications of this tomographic simulation approach will include the evaluation of study feasibility and the optimization of data analysis strategies.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages215-216
Number of pages2
Editionpt 1
ISBN (Print)0780302168
StatePublished - Dec 1 1991
EventProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, FL, USA
Duration: Oct 31 1991Nov 3 1991

Publication series

NameProceedings of the Annual Conference on Engineering in Medicine and Biology
Numberpt 1
Volume13
ISSN (Print)0589-1019

Other

OtherProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityOrlando, FL, USA
Period10/31/9111/3/91

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ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Hutchins, G. D. (1991). Simulation of signal recovery in PET studies of cerebral physiology and biochemistry. In Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 1 ed., pp. 215-216). (Proceedings of the Annual Conference on Engineering in Medicine and Biology; Vol. 13, No. pt 1). Publ by IEEE.