Simultaneous increases in respiration and sympathetic function during opiate detoxification

William E. Hoffman, Timothy McDonald, Richard Berkowitz

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This study evaluated the relationship between the sympathetic withdrawal response and increases in spontaneous ventilation during naltrexone treatment in opioid-dependent patients. Naltrexone was given in repeated increasing doses by orogastric tube to 16 opioid-dependent patients during propofol anesthesia. Sympathetic activity was evaluated in 64-second segments by low frequency heart rate variability (0.02-0.10 Hz) and minute ventilation was measured every 15 minutes. During naltrexone treatment, heart rate and blood pressure increased with no change in the electroencephalogram as measured by the bispectral index. Sympathetic activity increased five-fold and minute ventilation increased by 50% during naltrexone administration. There was a significant correlation between the time of the peak sympathetic response and peak ventilation (r = 0.83, p < 0.001). In three control patients, who received anesthesia for surgery without naltrexone treatment, no increases in sympathetic or respiratory parameters were seen. These results indicate that peak sympathetic and respiratory stimulation occur together during opiate receptor antagonism in opioid addicts.

Original languageEnglish (US)
Pages (from-to)205-210
Number of pages6
JournalJournal of Neurosurgical Anesthesiology
Volume10
Issue number4
StatePublished - Oct 1998
Externally publishedYes

Fingerprint

Opiate Alkaloids
Naltrexone
Respiration
Ventilation
Opioid Analgesics
Anesthesia
Heart Rate
Opioid Receptors
Propofol
Electroencephalography
Therapeutics
Blood Pressure

Keywords

  • Addiction
  • Anesthesia
  • Brain
  • Naltrexone
  • Opioids
  • Propofol
  • Sympathetic Ventilation

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology

Cite this

Simultaneous increases in respiration and sympathetic function during opiate detoxification. / Hoffman, William E.; McDonald, Timothy; Berkowitz, Richard.

In: Journal of Neurosurgical Anesthesiology, Vol. 10, No. 4, 10.1998, p. 205-210.

Research output: Contribution to journalArticle

Hoffman, William E. ; McDonald, Timothy ; Berkowitz, Richard. / Simultaneous increases in respiration and sympathetic function during opiate detoxification. In: Journal of Neurosurgical Anesthesiology. 1998 ; Vol. 10, No. 4. pp. 205-210.
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