Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease: A multicenter experience

R. H.J. Bandsma, M. A. Bozic, J. A. Fridell, M. H. Crull, J. Molleston, Y. Avitzur, Y. Mozer-Glassberg, R. P. Gonzalez-Peralta, M. Hodik, A. Fecteau, M. De Angelis, P. Durie, V. L. Ng

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: Diabetes is associated with increased morbidity and mortality in patients with cystic fibrosis (CF). While liver transplantation is well established for CF-related liver disease (CFLD), the role of simultaneous liver-pancreas transplantation is less understood. Methods: We polled 81 pediatric transplantation centers to identify and characterize subjects who had undergone simultaneous liver-pancreas transplantation and obtain opinions about this procedure in CFLD. Results: Fifty (61.7%) polled transplant centers responded and 94% reported that they would consider simultaneous liver-pancreas transplantation for CFLD and diabetes. A total of 8 patients with simultaneous liver-pancreas transplantation were identified with median follow up of 38. months. All patients had pre-existing diabetes. Exocrine and endocrine pancreatic function was initially restored in all patients with later functional loss in one patient. Body mass index Z-score increased between one year pre-transplantation and one year post-transplantation (P = 0.029). Conclusions: Patients with CFLD undergoing initial assessment for liver transplantation may benefit from consideration of simultaneous liver-pancreas transplantation.

Original languageEnglish (US)
Pages (from-to)471-477
Number of pages7
JournalJournal of Cystic Fibrosis
Issue number4
StatePublished - Jul 2014


  • Clinical
  • Cohort
  • Cystic fibrosis
  • Diabetes
  • Retrospective
  • Simultaneous liver pancreas transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

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