Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease

A multicenter experience

R. H J Bandsma, M. A. Bozic, J. A. Fridell, M. H. Crull, Jean Molleston, Y. Avitzur, Y. Mozer-Glassberg, R. P. Gonzalez-Peralta, M. Hodik, A. Fecteau, M. De Angelis, P. Durie, V. L. Ng

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Diabetes is associated with increased morbidity and mortality in patients with cystic fibrosis (CF). While liver transplantation is well established for CF-related liver disease (CFLD), the role of simultaneous liver-pancreas transplantation is less understood. Methods: We polled 81 pediatric transplantation centers to identify and characterize subjects who had undergone simultaneous liver-pancreas transplantation and obtain opinions about this procedure in CFLD. Results: Fifty (61.7%) polled transplant centers responded and 94% reported that they would consider simultaneous liver-pancreas transplantation for CFLD and diabetes. A total of 8 patients with simultaneous liver-pancreas transplantation were identified with median follow up of 38. months. All patients had pre-existing diabetes. Exocrine and endocrine pancreatic function was initially restored in all patients with later functional loss in one patient. Body mass index Z-score increased between one year pre-transplantation and one year post-transplantation (P = 0.029). Conclusions: Patients with CFLD undergoing initial assessment for liver transplantation may benefit from consideration of simultaneous liver-pancreas transplantation.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalJournal of Cystic Fibrosis
Volume13
Issue number4
DOIs
StatePublished - 2014

Fingerprint

Pancreas Transplantation
Cystic Fibrosis
Liver Transplantation
Liver Diseases
Transplantation
Body Mass Index
Pediatrics
Morbidity
Transplants
Mortality

Keywords

  • Clinical
  • Cohort
  • Cystic fibrosis
  • Diabetes
  • Retrospective
  • Simultaneous liver pancreas transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease : A multicenter experience. / Bandsma, R. H J; Bozic, M. A.; Fridell, J. A.; Crull, M. H.; Molleston, Jean; Avitzur, Y.; Mozer-Glassberg, Y.; Gonzalez-Peralta, R. P.; Hodik, M.; Fecteau, A.; De Angelis, M.; Durie, P.; Ng, V. L.

In: Journal of Cystic Fibrosis, Vol. 13, No. 4, 2014, p. 471-477.

Research output: Contribution to journalArticle

Bandsma, RHJ, Bozic, MA, Fridell, JA, Crull, MH, Molleston, J, Avitzur, Y, Mozer-Glassberg, Y, Gonzalez-Peralta, RP, Hodik, M, Fecteau, A, De Angelis, M, Durie, P & Ng, VL 2014, 'Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease: A multicenter experience', Journal of Cystic Fibrosis, vol. 13, no. 4, pp. 471-477. https://doi.org/10.1016/j.jcf.2013.12.010
Bandsma, R. H J ; Bozic, M. A. ; Fridell, J. A. ; Crull, M. H. ; Molleston, Jean ; Avitzur, Y. ; Mozer-Glassberg, Y. ; Gonzalez-Peralta, R. P. ; Hodik, M. ; Fecteau, A. ; De Angelis, M. ; Durie, P. ; Ng, V. L. / Simultaneous liver-pancreas transplantation for cystic fibrosis-related liver disease : A multicenter experience. In: Journal of Cystic Fibrosis. 2014 ; Vol. 13, No. 4. pp. 471-477.
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