Simultaneous management of blood flow and IOP in glaucoma

Alon Harris, Christian Jonescu-Cuypers, Bruce Martin, Larry Kagemann, Miriam Zalish, Hannah J. Garzozi

Research output: Contribution to journalArticle

33 Scopus citations


Factors other than intraocular pressure (IOP) elevation must be involved in initiation and progression of glaucoma. An additional element in disease causation may be ischemia in the retina and optic nerve head. Ischemic damage to neurons in the CNS is similar mechanistically and histopathologically to changes seen in glaucoma. Further, glaucoma patients with normal IOP show clear evidence for cerebral and ocular ischemia. Aging and atherosclerosis reduce the ability of the eye to autoregulate blood flow when ocular perfusion pressure changes: the dependence of blood flow on perfusion pressure links ischemia to IOP. Consequently, neuroprotective treatments for glaucoma should be designed to both reduce IOP and improve ocular nutrient delivery.

Original languageEnglish (US)
Pages (from-to)336-341
Number of pages6
JournalActa Ophthalmologica Scandinavica
Issue number4
StatePublished - Aug 6 2001


  • Carbonic anhydrase
  • Glaucoma
  • Intraocular pressure
  • Ischemia

ASJC Scopus subject areas

  • Ophthalmology

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    Harris, A., Jonescu-Cuypers, C., Martin, B., Kagemann, L., Zalish, M., & Garzozi, H. J. (2001). Simultaneous management of blood flow and IOP in glaucoma. Acta Ophthalmologica Scandinavica, 79(4), 336-341.