Simultaneous toxicities in a child on multiple anticonvulsants

Sarah Isis R. Delima, Laurence E. Walsh, Meredith R. Golomb

Research output: Contribution to journalArticle

2 Scopus citations


It is rare to develop simultaneous toxicities while on anticonvulsants. This article presents a 3 1/2-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection. These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam. This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

Original languageEnglish (US)
Pages (from-to)1054-1057
Number of pages4
JournalJournal of Child Neurology
Issue number9
StatePublished - Sep 3 2008


  • Bone marrow
  • Epilepsy
  • Hepatotoxicity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

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