Simultaneous toxicities in a child on multiple anticonvulsants

Sarah Isis R Delima, Larry Walsh, Meredith Golomb

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

It is rare to develop simultaneous toxicities while on anticonvulsants. This article presents a 3 1/2-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection. These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam. This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

Original languageEnglish
Pages (from-to)1054-1057
Number of pages4
JournalJournal of Child Neurology
Volume23
Issue number9
DOIs
StatePublished - 2008

Fingerprint

Valproic Acid
Phenytoin
Anticonvulsants
Human parainfluenza virus 3
Paramyxoviridae Infections
Lorazepam
Virus Diseases
Seizures
Bone Marrow
lamotrigine

Keywords

  • Bone marrow
  • Epilepsy
  • Hepatotoxicity

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

Cite this

Simultaneous toxicities in a child on multiple anticonvulsants. / Delima, Sarah Isis R; Walsh, Larry; Golomb, Meredith.

In: Journal of Child Neurology, Vol. 23, No. 9, 2008, p. 1054-1057.

Research output: Contribution to journalArticle

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