Single isomer versus racemate

Is there a difference? Clinical comparisons in allergy and gastroenterology

David A. Flockhart, Harold S. Nelson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Many commonly prescribed drugs exist as a mixture of two distinct chiral isomer forms (enantiomers), each with its own unique chemistry, receptor affinity, and pharmacokinetic profile. Much is unknown concerning the clinical utility of these single enantiomers. This review of the stereoisomers of two commonly used drugs - albuterol for asthma and omeprazole for gastroesophageal reflux disease (GERD) and peptic ulcers - examines the improved efficacy, pharmacokinetics, decreased adverse effects, and fewer drug-drug interactions associated with single enantiomers.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalCNS Spectrums
Volume7
Issue number4 SUPPL. 1
StatePublished - 2002

Fingerprint

Gastroenterology
Hypersensitivity
Pharmacokinetics
Pharmaceutical Preparations
Stereoisomerism
Omeprazole
Albuterol
Gastroesophageal Reflux
Peptic Ulcer
Drug Interactions
Asthma

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Single isomer versus racemate : Is there a difference? Clinical comparisons in allergy and gastroenterology. / Flockhart, David A.; Nelson, Harold S.

In: CNS Spectrums, Vol. 7, No. 4 SUPPL. 1, 2002, p. 23-27.

Research output: Contribution to journalArticle

Flockhart, David A. ; Nelson, Harold S. / Single isomer versus racemate : Is there a difference? Clinical comparisons in allergy and gastroenterology. In: CNS Spectrums. 2002 ; Vol. 7, No. 4 SUPPL. 1. pp. 23-27.
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