Single-trial speech suppression of auditory cortex activity in humans

Adeen Flinker, Edward F. Chang, Heidi E. Kirsch, Nicholas Barbaro, Nathan E. Crone, Robert T. Knight

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

The human auditory cortex is engaged in monitoring the speech of interlocutors as well as self-generated speech. During vocalization, auditory cortex activity is reported to be suppressed, an effect often attributed to the influence of an efference copy from motor cortex. Single-unit studies in non-human primates have demonstrated a rich dynamic range of single-trial auditory responses to self-speech consisting of suppressed, nonsuppressed and excited auditory neurons. However, human research using noninvasive methods has only reported suppression of averaged auditory cortex responses to self-generated speech. We addressed this discrepancy by recording electrocorticographic activity from neurosurgical subjects performing auditory repetition tasks. We observed that the degree of suppression varied across different regions of auditory cortex, revealing a variety of suppressed and nonsuppressed responses during vocalization. Importantly, single-trial high-gamma power (γHigh, 70-150 Hz) robustly tracked individual auditory events and exhibited stable responses across trials for suppressed and nonsuppressed regions.

Original languageEnglish (US)
Pages (from-to)16643-16650
Number of pages8
JournalJournal of Neuroscience
Volume30
Issue number49
DOIs
StatePublished - Dec 8 2010
Externally publishedYes

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Auditory Cortex
Human Activities
Motor Cortex
Primates
Neurons
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Flinker, A., Chang, E. F., Kirsch, H. E., Barbaro, N., Crone, N. E., & Knight, R. T. (2010). Single-trial speech suppression of auditory cortex activity in humans. Journal of Neuroscience, 30(49), 16643-16650. https://doi.org/10.1523/JNEUROSCI.1809-10.2010

Single-trial speech suppression of auditory cortex activity in humans. / Flinker, Adeen; Chang, Edward F.; Kirsch, Heidi E.; Barbaro, Nicholas; Crone, Nathan E.; Knight, Robert T.

In: Journal of Neuroscience, Vol. 30, No. 49, 08.12.2010, p. 16643-16650.

Research output: Contribution to journalArticle

Flinker, A, Chang, EF, Kirsch, HE, Barbaro, N, Crone, NE & Knight, RT 2010, 'Single-trial speech suppression of auditory cortex activity in humans', Journal of Neuroscience, vol. 30, no. 49, pp. 16643-16650. https://doi.org/10.1523/JNEUROSCI.1809-10.2010
Flinker A, Chang EF, Kirsch HE, Barbaro N, Crone NE, Knight RT. Single-trial speech suppression of auditory cortex activity in humans. Journal of Neuroscience. 2010 Dec 8;30(49):16643-16650. https://doi.org/10.1523/JNEUROSCI.1809-10.2010
Flinker, Adeen ; Chang, Edward F. ; Kirsch, Heidi E. ; Barbaro, Nicholas ; Crone, Nathan E. ; Knight, Robert T. / Single-trial speech suppression of auditory cortex activity in humans. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 49. pp. 16643-16650.
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