Singleton deletions throughout the genome increase risk of bipolar disorder

D. Zhang, L. Cheng, Y. Qian, N. Alliey-Rodriguez, J. R. Kelsoe, T. Greenwood, C. Nievergelt, T. B. Barrett, R. McKinney, N. Schork, E. N. Smith, C. Bloss, J. Nurnberger, H. J. Edenberg, T. Foroud, W. Sheftner, W. B. Lawson, E. A. Nwulia, M. Hipolito, W. CoryellJ. Rice, W. Byerley, F. McMahon, T. G. Schulze, W. Berrettini, J. B. Potash, P. L. Belmonte, P. P. Zandi, M. G. McInnis, S. Zöllner, D. Craig, S. Szelinger, D. Koller, S. L. Christian, C. Liu, E. S. Gershon

Research output: Contribution to journalArticle

113 Scopus citations

Abstract

An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genome-wide copy number variant (CNV) survey of 1001 cases and 1034 controls using the Affymetrix single nucleotide polymorphism (SNP) 6.0 SNP and CNV platform. Singleton deletions (deletions that appear only once in the dataset) more than 100 kb in length are present in 16.2% of BD cases in contrast to 12.3% of controls (permutation P=0.007). This effect was more pronounced for age at onset of mania ≤18 years old. Our results strongly suggest that BD can result from the effects of multiple rare structural variants.

Original languageEnglish (US)
Pages (from-to)376-380
Number of pages5
JournalMolecular Psychiatry
Volume14
Issue number4
DOIs
StatePublished - Apr 1 2009

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Keywords

  • Bipolar disorder
  • Copy number variation
  • Genetics
  • Singleton

ASJC Scopus subject areas

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

Zhang, D., Cheng, L., Qian, Y., Alliey-Rodriguez, N., Kelsoe, J. R., Greenwood, T., Nievergelt, C., Barrett, T. B., McKinney, R., Schork, N., Smith, E. N., Bloss, C., Nurnberger, J., Edenberg, H. J., Foroud, T., Sheftner, W., Lawson, W. B., Nwulia, E. A., Hipolito, M., ... Gershon, E. S. (2009). Singleton deletions throughout the genome increase risk of bipolar disorder. Molecular Psychiatry, 14(4), 376-380. https://doi.org/10.1038/mp.2008.144