Sirt1, notch and stem cell "age asymmetry"

Charlie R. Mantel, Rui Hong Wang, Chuxia Deng, Hal E. Broxmeyer

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Almost all complex multicellular organisms on earth utilize oxygen for the production of energy. This strategy carries the risk for damaging ROS to be generated and so these biochemical pathways must be highly regulated. Because of this, regulation of oxidative-phosphorylation is tightly coordinated with every aspect of cellular physiology, including stem cell regulation during embryonic development and in adult organisms. The protein-deacetylase, SIRT1, has received much attention because of its roles in oxygen metabolism, cellular stress response, aging, and has been investigated in various species and cell types including embryonic stem cells. However, there is a dearth of information on SIRT1 in adult stem cells, which have a pivotal role in adult aging processes. Here, we discuss the potential relationships between SIRT1 and the surface receptor protein, Notch, with stem cell self-renewal, asymmetric cell division, signaling and stem cell aging.

Original languageEnglish
Pages (from-to)2821-2825
Number of pages5
JournalCell Cycle
Volume7
Issue number18
StatePublished - Sep 15 2008

Fingerprint

Stem cells
Stem Cells
Asymmetric Cell Division
Notch Receptors
Oxygen
Adult Stem Cells
Cell Aging
Oxidative Phosphorylation
Embryonic Stem Cells
Aging of materials
Embryonic Development
Membrane Proteins
Physiology
Proteins
Metabolism
Earth (planet)
Cells
Cell Self Renewal

Keywords

  • Aging
  • Asymmetry
  • HES1
  • Nanog
  • Notch
  • Sirt1
  • Stem cell

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

Cite this

Sirt1, notch and stem cell "age asymmetry". / Mantel, Charlie R.; Wang, Rui Hong; Deng, Chuxia; Broxmeyer, Hal E.

In: Cell Cycle, Vol. 7, No. 18, 15.09.2008, p. 2821-2825.

Research output: Contribution to journalReview article

Mantel, CR, Wang, RH, Deng, C & Broxmeyer, HE 2008, 'Sirt1, notch and stem cell "age asymmetry"', Cell Cycle, vol. 7, no. 18, pp. 2821-2825. https://doi.org/10.4161/cc.7.18.6517
Mantel, Charlie R. ; Wang, Rui Hong ; Deng, Chuxia ; Broxmeyer, Hal E. / Sirt1, notch and stem cell "age asymmetry". In: Cell Cycle. 2008 ; Vol. 7, No. 18. pp. 2821-2825.
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