Sirt1, notch and stem cell "age asymmetry"

Charlie R. Mantel, Rui Hong Wang, Chuxia Deng, Hal E. Broxmeyer

Research output: Contribution to journalReview article

7 Scopus citations


Almost all complex multicellular organisms on earth utilize oxygen for the production of energy. This strategy carries the risk for damaging ROS to be generated and so these biochemical pathways must be highly regulated. Because of this, regulation of oxidative-phosphorylation is tightly coordinated with every aspect of cellular physiology, including stem cell regulation during embryonic development and in adult organisms. The protein-deacetylase, SIRT1, has received much attention because of its roles in oxygen metabolism, cellular stress response, aging, and has been investigated in various species and cell types including embryonic stem cells. However, there is a dearth of information on SIRT1 in adult stem cells, which have a pivotal role in adult aging processes. Here, we discuss the potential relationships between SIRT1 and the surface receptor protein, Notch, with stem cell self-renewal, asymmetric cell division, signaling and stem cell aging.

Original languageEnglish (US)
Pages (from-to)2821-2825
Number of pages5
JournalCell Cycle
Issue number18
StatePublished - Sep 15 2008


  • Aging
  • Asymmetry
  • HES1
  • Nanog
  • Notch
  • Sirt1
  • Stem cell

ASJC Scopus subject areas

  • Cell Biology
  • Biochemistry
  • Molecular Biology

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