SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. HirscheyHaim Y. Cohen

Research output: Contribution to journalArticle

Abstract

How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

Original languageEnglish (US)
Pages (from-to)4127-4143.e8
JournalCell Reports
Volume29
Issue number12
DOIs
StatePublished - Dec 17 2019

Keywords

  • PPARα
  • SIRT6
  • beta-oxidation
  • deacetylase
  • fasting
  • liver

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., Nahum, L., Avivi, M. Y., Roichman, A., Kanfi, Y., Gertler, A. A., Doniger, T., Ilkayeva, O. R., Abramovich, I., Yaron, O., Lerrer, B., Gottlieb, E., Harris, R. A., Gerber, D., ... Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports, 29(12), 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067