SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Shoshana Naiman, Frank K. Huynh, Reuven Gil, Yair Glick, Yael Shahar, Noga Touitou, Liat Nahum, Matan Y. Avivi, Asael Roichman, Yariv Kanfi, Asaf A. Gertler, Tirza Doniger, Olga R. Ilkayeva, Ifat Abramovich, Orly Yaron, Batia Lerrer, Eyal Gottlieb, Robert A. Harris, Doron Gerber, Matthew D. HirscheyHaim Y. Cohen

Research output: Contribution to journalArticle

Abstract

How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

Original languageEnglish (US)
Pages (from-to)4127-4143.e8
JournalCell Reports
Volume29
Issue number12
DOIs
StatePublished - Dec 17 2019

Fingerprint

Peroxisome Proliferator-Activated Receptors
Metabolic Networks and Pathways
Pyruvic Acid
Fasting
Fatty Acids
Chemical activation
Fats
Food
Oxidation
Liver
Enzymes
Nutrients

Keywords

  • beta-oxidation
  • deacetylase
  • fasting
  • liver
  • PPARα
  • SIRT6

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Naiman, S., Huynh, F. K., Gil, R., Glick, Y., Shahar, Y., Touitou, N., ... Cohen, H. Y. (2019). SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports, 29(12), 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. / Naiman, Shoshana; Huynh, Frank K.; Gil, Reuven; Glick, Yair; Shahar, Yael; Touitou, Noga; Nahum, Liat; Avivi, Matan Y.; Roichman, Asael; Kanfi, Yariv; Gertler, Asaf A.; Doniger, Tirza; Ilkayeva, Olga R.; Abramovich, Ifat; Yaron, Orly; Lerrer, Batia; Gottlieb, Eyal; Harris, Robert A.; Gerber, Doron; Hirschey, Matthew D.; Cohen, Haim Y.

In: Cell Reports, Vol. 29, No. 12, 17.12.2019, p. 4127-4143.e8.

Research output: Contribution to journalArticle

Naiman, S, Huynh, FK, Gil, R, Glick, Y, Shahar, Y, Touitou, N, Nahum, L, Avivi, MY, Roichman, A, Kanfi, Y, Gertler, AA, Doniger, T, Ilkayeva, OR, Abramovich, I, Yaron, O, Lerrer, B, Gottlieb, E, Harris, RA, Gerber, D, Hirschey, MD & Cohen, HY 2019, 'SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα', Cell Reports, vol. 29, no. 12, pp. 4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067
Naiman S, Huynh FK, Gil R, Glick Y, Shahar Y, Touitou N et al. SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. Cell Reports. 2019 Dec 17;29(12):4127-4143.e8. https://doi.org/10.1016/j.celrep.2019.11.067
Naiman, Shoshana ; Huynh, Frank K. ; Gil, Reuven ; Glick, Yair ; Shahar, Yael ; Touitou, Noga ; Nahum, Liat ; Avivi, Matan Y. ; Roichman, Asael ; Kanfi, Yariv ; Gertler, Asaf A. ; Doniger, Tirza ; Ilkayeva, Olga R. ; Abramovich, Ifat ; Yaron, Orly ; Lerrer, Batia ; Gottlieb, Eyal ; Harris, Robert A. ; Gerber, Doron ; Hirschey, Matthew D. ; Cohen, Haim Y. / SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα. In: Cell Reports. 2019 ; Vol. 29, No. 12. pp. 4127-4143.e8.
@article{4f6c7c4756334d07b06b5d8072ce6222,
title = "SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα",
abstract = "How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.",
keywords = "beta-oxidation, deacetylase, fasting, liver, PPARα, SIRT6",
author = "Shoshana Naiman and Huynh, {Frank K.} and Reuven Gil and Yair Glick and Yael Shahar and Noga Touitou and Liat Nahum and Avivi, {Matan Y.} and Asael Roichman and Yariv Kanfi and Gertler, {Asaf A.} and Tirza Doniger and Ilkayeva, {Olga R.} and Ifat Abramovich and Orly Yaron and Batia Lerrer and Eyal Gottlieb and Harris, {Robert A.} and Doron Gerber and Hirschey, {Matthew D.} and Cohen, {Haim Y.}",
year = "2019",
month = "12",
day = "17",
doi = "10.1016/j.celrep.2019.11.067",
language = "English (US)",
volume = "29",
pages = "4127--4143.e8",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",

}

TY - JOUR

T1 - SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

AU - Naiman, Shoshana

AU - Huynh, Frank K.

AU - Gil, Reuven

AU - Glick, Yair

AU - Shahar, Yael

AU - Touitou, Noga

AU - Nahum, Liat

AU - Avivi, Matan Y.

AU - Roichman, Asael

AU - Kanfi, Yariv

AU - Gertler, Asaf A.

AU - Doniger, Tirza

AU - Ilkayeva, Olga R.

AU - Abramovich, Ifat

AU - Yaron, Orly

AU - Lerrer, Batia

AU - Gottlieb, Eyal

AU - Harris, Robert A.

AU - Gerber, Doron

AU - Hirschey, Matthew D.

AU - Cohen, Haim Y.

PY - 2019/12/17

Y1 - 2019/12/17

N2 - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

AB - How the pro-longevity enzyme SIRT6 coordinates between various metabolic pathways is still obscure. Here, Naiman et al. show that SIRT6 activates PPARα to promote fatty acid beta oxidation and inhibit pyruvate oxidation during fasting. This ultimately decides the energy source under nutrient-limited conditions, promoting fat usage over other energy sources.

KW - beta-oxidation

KW - deacetylase

KW - fasting

KW - liver

KW - PPARα

KW - SIRT6

UR - http://www.scopus.com/inward/record.url?scp=85076344864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076344864&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.11.067

DO - 10.1016/j.celrep.2019.11.067

M3 - Article

C2 - 31851938

AN - SCOPUS:85076344864

VL - 29

SP - 4127-4143.e8

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 12

ER -