Sisters in arms: Myeloid and tubular epithelial cells shape renal innate immunity

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

The importance of innate immunity for survival is underscored by its presence at almost every level of the evolutionary tree of life. The task of "danger" recognition by the innate immune system is carried out by a broad class of pattern recognition receptors. These receptors are expressed in both hematopoietic and nonhematopoi-etic cells such as renal epithelial cells. Upon activation, pattern recognition receptors induce essentially two types of defensive responses: inflammation and phagocytosis. In this review, we highlight evidence that renal epithelial cells are endowed with such defensive capabilities and as such fully participate in renal innate immune responses.

Original languageEnglish (US)
Pages (from-to)1243-1251
Number of pages9
JournalAmerican Journal of Physiology - Renal Physiology
Volume304
Issue number10
DOIs
StatePublished - Jun 11 2013

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Keywords

  • Endotoxin
  • Epithelial cells
  • Innate immunity
  • Pattern recognition receptors
  • Toll-like receptor

ASJC Scopus subject areas

  • Physiology
  • Urology

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