SK channels and ventricular arrhythmias in heart failure

Po Cheng Chang, Peng Sheng Chen

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Small-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca<sup>2+</sup>. The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of anti-arrhythmic therapy, drug safety is still one of the major concerns.

Original languageEnglish (US)
Pages (from-to)508-514
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume25
Issue number6
DOIs
StatePublished - Aug 1 2015

Fingerprint

Anti-Arrhythmia Agents
Cardiac Myocytes
Cardiac Arrhythmias
Heart Failure
Safety
Drug Therapy
Proteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

SK channels and ventricular arrhythmias in heart failure. / Chang, Po Cheng; Chen, Peng Sheng.

In: Trends in Cardiovascular Medicine, Vol. 25, No. 6, 01.08.2015, p. 508-514.

Research output: Contribution to journalReview article

@article{af3ff317852243178cb911dc544998a2,
title = "SK channels and ventricular arrhythmias in heart failure",
abstract = "Small-conductance Ca2+-activated K+ (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca2+. The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of anti-arrhythmic therapy, drug safety is still one of the major concerns.",
author = "Chang, {Po Cheng} and Chen, {Peng Sheng}",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.tcm.2015.01.010",
language = "English (US)",
volume = "25",
pages = "508--514",
journal = "Trends in Cardiovascular Medicine",
issn = "1050-1738",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - SK channels and ventricular arrhythmias in heart failure

AU - Chang, Po Cheng

AU - Chen, Peng Sheng

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Small-conductance Ca2+-activated K+ (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca2+. The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of anti-arrhythmic therapy, drug safety is still one of the major concerns.

AB - Small-conductance Ca2+-activated K+ (SK) currents are important in the repolarization of normal atrial (but not ventricular) cardiomyocytes. However, recent studies showed that the SK currents are upregulated in failing ventricular cardiomyocytes, along with increased SK channel protein expression and enhanced sensitivity to intracellular Ca2+. The SK channel activation may be either anti-arrhythmic or pro-arrhythmic, depending on the underlying clinical situations. While the SK channel is a new target of anti-arrhythmic therapy, drug safety is still one of the major concerns.

UR - http://www.scopus.com/inward/record.url?scp=84939257383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939257383&partnerID=8YFLogxK

U2 - 10.1016/j.tcm.2015.01.010

DO - 10.1016/j.tcm.2015.01.010

M3 - Review article

C2 - 25743622

AN - SCOPUS:84939257383

VL - 25

SP - 508

EP - 514

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

SN - 1050-1738

IS - 6

ER -