Skeletal accumulation of bisphosphonates: Implications for osteoporosis treatment

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Background: Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. Objective: To review concepts related to the biological effects of BP accumulation in the skeleton. Methods: Articles concerning skeletal accumulation of BP treatment were identified. Results/conclusions: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.

Original languageEnglish (US)
Pages (from-to)1371-1378
Number of pages8
JournalExpert Opinion on Drug Metabolism and Toxicology
Volume4
Issue number11
DOIs
StatePublished - Nov 1 2008

Fingerprint

Diphosphonates
Osteoporosis
Bone
Bone Matrix
Bone Remodeling
Biological Factors
Skeleton
Gold
Pharmacology
Pharmaceutical Preparations

Keywords

  • Anti-remodeling agents
  • Bisphosphonates
  • Osteonecrosis of the jaw
  • Osteoporosis treatment
  • Remodeling suppression

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

Cite this

Skeletal accumulation of bisphosphonates : Implications for osteoporosis treatment. / Allen, Matthew R.

In: Expert Opinion on Drug Metabolism and Toxicology, Vol. 4, No. 11, 01.11.2008, p. 1371-1378.

Research output: Contribution to journalReview article

@article{dbc46bd605dc41c29700ff387fa2f06e,
title = "Skeletal accumulation of bisphosphonates: Implications for osteoporosis treatment",
abstract = "Background: Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. Objective: To review concepts related to the biological effects of BP accumulation in the skeleton. Methods: Articles concerning skeletal accumulation of BP treatment were identified. Results/conclusions: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.",
keywords = "Anti-remodeling agents, Bisphosphonates, Osteonecrosis of the jaw, Osteoporosis treatment, Remodeling suppression",
author = "Allen, {Matthew R.}",
year = "2008",
month = "11",
day = "1",
doi = "10.1517/17425255.4.11.1371",
language = "English (US)",
volume = "4",
pages = "1371--1378",
journal = "Expert Opinion on Drug Metabolism and Toxicology",
issn = "1742-5255",
publisher = "Informa Healthcare",
number = "11",

}

TY - JOUR

T1 - Skeletal accumulation of bisphosphonates

T2 - Implications for osteoporosis treatment

AU - Allen, Matthew R.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Background: Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. Objective: To review concepts related to the biological effects of BP accumulation in the skeleton. Methods: Articles concerning skeletal accumulation of BP treatment were identified. Results/conclusions: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.

AB - Background: Bisphosphonates (BPs), the gold-standard pharmacological treatment for osteoporosis, are unique in that they become physically bound to the bone matrix and therefore accumulate over time. This skeletal accumulation has important physiological implications that are not completely understood. Objective: To review concepts related to the biological effects of BP accumulation in the skeleton. Methods: Articles concerning skeletal accumulation of BP treatment were identified. Results/conclusions: Skeletal accumulation of BP, dictated by both chemical and biological factors, is dose-dependent, differs among skeletal sites and likely differs among the various BPs. Bisphosphonate embedded within the skeletal matrix has lasting biological effects, the results of which have both positive and negative implications for bone remodeling. As alternative anti-remodeling agents gain approval for treatment of osteoporosis, the property of skeletal accumulation will likely be unique to BPs and therefore may be the property that determines the future use of this drug class.

KW - Anti-remodeling agents

KW - Bisphosphonates

KW - Osteonecrosis of the jaw

KW - Osteoporosis treatment

KW - Remodeling suppression

UR - http://www.scopus.com/inward/record.url?scp=56749118082&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749118082&partnerID=8YFLogxK

U2 - 10.1517/17425255.4.11.1371

DO - 10.1517/17425255.4.11.1371

M3 - Review article

C2 - 18950279

AN - SCOPUS:56749118082

VL - 4

SP - 1371

EP - 1378

JO - Expert Opinion on Drug Metabolism and Toxicology

JF - Expert Opinion on Drug Metabolism and Toxicology

SN - 1742-5255

IS - 11

ER -