Skeletal Assessments in the Nonhuman Primate

John L. Vahle, Yanfei L. Ma, David Burr

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

In the context of drug development programs, studies of the nonhuman primate (NHP) often play a prominent role in skeletal assessment. Many therapeutic agents with a mechanism of action involving the skeleton use the monkey for bone efficacy and safety assessments because of the similarities between the skeletons of NHPs and humans. This chapter provides scientists engaged in drug development programs an understanding of the unique role that the NHP can play in characterizing skeletal effects. Basic principles of skeletal structure and function are reviewed, with an emphasis on comparisons of the NHP skeleton to that of humans and rodents. A comprehensive set of methodologies to assess the NHP skeleton are available and are summarized in this chapter. These methods include bone densitometry, biomechanical testing, biomarkers of bone formation and resorption, histology, and histomorphometry. Practical aspects for implementing these measures in routine toxicity studies are briefly described in this chapter.

Original languageEnglish (US)
Title of host publicationThe Nonhuman Primate in Nonclinical Drug Development and Safety Assessment
PublisherElsevier Inc.
Pages605-625
Number of pages21
ISBN (Print)9780124171466, 9780124171442
DOIs
StatePublished - Mar 12 2015

Fingerprint

Skeleton
Primates
Bone and Bones
Densitometry
Bone Resorption
Osteogenesis
Pharmaceutical Preparations
Haplorhini
Rodentia
Histology
Biomarkers
Safety
Therapeutics

Keywords

  • Biomechanics
  • Bone
  • Bone biomarkers
  • Densitometry
  • Histomorphometry
  • Nonhuman primate (NHP)
  • Skeleton

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Vahle, J. L., Ma, Y. L., & Burr, D. (2015). Skeletal Assessments in the Nonhuman Primate. In The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment (pp. 605-625). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-417144-2.00032-9

Skeletal Assessments in the Nonhuman Primate. / Vahle, John L.; Ma, Yanfei L.; Burr, David.

The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. Elsevier Inc., 2015. p. 605-625.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vahle, JL, Ma, YL & Burr, D 2015, Skeletal Assessments in the Nonhuman Primate. in The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. Elsevier Inc., pp. 605-625. https://doi.org/10.1016/B978-0-12-417144-2.00032-9
Vahle JL, Ma YL, Burr D. Skeletal Assessments in the Nonhuman Primate. In The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. Elsevier Inc. 2015. p. 605-625 https://doi.org/10.1016/B978-0-12-417144-2.00032-9
Vahle, John L. ; Ma, Yanfei L. ; Burr, David. / Skeletal Assessments in the Nonhuman Primate. The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment. Elsevier Inc., 2015. pp. 605-625
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