Skeletal microdamage: Less about biomechanics and more about remodeling

Matthew R. Allen, David B. Burr

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones' biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.

Original languageEnglish (US)
Pages (from-to)24-30
Number of pages7
JournalClinical Reviews in Bone and Mineral Metabolism
Volume6
Issue number1-2
DOIs
StatePublished - Jun 1 2008

Keywords

  • Aging
  • Microcracks
  • Targeted remodeling
  • Toughness

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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