Skeletal microdamage

Less about biomechanics and more about remodeling

Matthew Allen, David Burr

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones' biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalClinical Reviews in Bone and Mineral Metabolism
Volume6
Issue number1-2
DOIs
StatePublished - Jun 2008

Fingerprint

Bone Remodeling
Biomechanical Phenomena
Osteocytes
Bone and Bones

Keywords

  • Aging
  • Microcracks
  • Targeted remodeling
  • Toughness

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Skeletal microdamage : Less about biomechanics and more about remodeling. / Allen, Matthew; Burr, David.

In: Clinical Reviews in Bone and Mineral Metabolism, Vol. 6, No. 1-2, 06.2008, p. 24-30.

Research output: Contribution to journalArticle

@article{18128bb82c21492892267d24f206854f,
title = "Skeletal microdamage: Less about biomechanics and more about remodeling",
abstract = "The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones' biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.",
keywords = "Aging, Microcracks, Targeted remodeling, Toughness",
author = "Matthew Allen and David Burr",
year = "2008",
month = "6",
doi = "10.1007/s12018-008-9015-5",
language = "English",
volume = "6",
pages = "24--30",
journal = "Clinical Reviews in Bone and Mineral Metabolism",
issn = "1534-8644",
publisher = "Humana Press",
number = "1-2",

}

TY - JOUR

T1 - Skeletal microdamage

T2 - Less about biomechanics and more about remodeling

AU - Allen, Matthew

AU - Burr, David

PY - 2008/6

Y1 - 2008/6

N2 - The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones' biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.

AB - The mechanical consequences of skeletal microdamage have been clearly documented using various experimental methods, yet recent experiments suggest that physiological levels of microdamage accumulation are not sufficient to compromise the bones' biomechanical properties. While great advances have been made in our understanding of the biomechanical implications of microdamage, less is known concerning the physiological role of microdamage in bone remodeling. Microdamage has been shown to act as a signal for bone remodeling, likely through a disruption of the osteocyte-canalicular network. Interestingly, age-related increases in microdamage are not accompanied by increases in bone remodeling suggesting that the physiological mechanisms which link microdamage and remodeling are compromised with aging.

KW - Aging

KW - Microcracks

KW - Targeted remodeling

KW - Toughness

UR - http://www.scopus.com/inward/record.url?scp=58149101532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149101532&partnerID=8YFLogxK

U2 - 10.1007/s12018-008-9015-5

DO - 10.1007/s12018-008-9015-5

M3 - Article

VL - 6

SP - 24

EP - 30

JO - Clinical Reviews in Bone and Mineral Metabolism

JF - Clinical Reviews in Bone and Mineral Metabolism

SN - 1534-8644

IS - 1-2

ER -