Skeletal muscle Ca2+ mishandling

Another effect of bone-to-muscle signaling

Jenna Regan, David L. Waning, Theresa Guise

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Our appreciation of crosstalk between muscle and bone has recently expanded beyond mechanical force-driven events to encompass a variety of signaling factors originating in one tissue and communicating to the other. While the recent identification of new 'myokines' has shifted some focus to the role of muscle in this partnership, bone-derived factors and their effects on skeletal muscle should not be overlooked. This review summarizes some previously known mediators of bone-to-muscle signaling and also recent work identifying a new role for bone-derived TGF-β as a cause of skeletal muscle weakness in the setting of cancer-induced bone destruction. Oxidation of the ryanodine receptor/calcium release channel (RyR1) in skeletal muscle occurs via a TGF-β-Nox4-RyR1 axis and leads to calcium mishandling and decreased muscle function. Multiple points of potential therapeutic intervention were identified, from preventing the bone destruction to stabilizing the RYR1 calcium channel. This new data reinforces the concept that bone can be an important source of signaling factors in pathphysiological settings.

Original languageEnglish (US)
Pages (from-to)24-29
Number of pages6
JournalSeminars in Cell and Developmental Biology
Volume49
DOIs
StatePublished - Jan 1 2016

Fingerprint

Skeletal Muscle
Bone and Bones
Muscles
Ryanodine Receptor Calcium Release Channel
Bone Neoplasms
Muscle Weakness
Calcium Channels
Calcium
Therapeutics

Keywords

  • Bone
  • Calcium handling
  • Skeletal muscle
  • TGF-β

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Skeletal muscle Ca2+ mishandling : Another effect of bone-to-muscle signaling. / Regan, Jenna; Waning, David L.; Guise, Theresa.

In: Seminars in Cell and Developmental Biology, Vol. 49, 01.01.2016, p. 24-29.

Research output: Contribution to journalArticle

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