Skeletal muscle-derived progenitor cells exhibit neural competence

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Skeletal muscle contains heterogenous progenitor cells that give rise to muscle, hematopoietic cells and bone. The exact phenotypic definition of skeletal muscle progenitor cells has not been fully elucidated nor the potential of these cells to differentiate into neurons. Here, we demonstrate that phenotypically homogenous skeletal muscle progenitor cells defined as Lin -CD45-CDII7-CD90+ cells express neural stem cell markers and are responsive to neural induction signals. When exposed to neural induction medium containing basic fibroblast growth factor and brain-derived neurotrophic factor, skeletal muscle progenitor cells dramatically changed their cell morphology, became post-mitotic and began expressing neuronal markers. These results reveal unexpected potentials of muscle progenitor cells and suggest that these cells may potentially be used in cell-based therapies to replace damaged neurons.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNeuroReport
Volume17
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Mental Competency
Muscle Cells
Skeletal Muscle
Stem Cells
Neurons
Neural Stem Cells
Brain-Derived Neurotrophic Factor
Fibroblast Growth Factor 2
Cell- and Tissue-Based Therapy
Bone and Bones

Keywords

  • Cell-based therapy
  • Neural differentiation
  • Progenitor cells
  • Skeletal muscle

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Skeletal muscle-derived progenitor cells exhibit neural competence. / Kondo, Takako; Case, Jamie; Srour, Edward; Hashino, Eri.

In: NeuroReport, Vol. 17, No. 1, 01.2006, p. 1-4.

Research output: Contribution to journalArticle

@article{e8b76be513284a77914cf8c20bccf663,
title = "Skeletal muscle-derived progenitor cells exhibit neural competence",
abstract = "Skeletal muscle contains heterogenous progenitor cells that give rise to muscle, hematopoietic cells and bone. The exact phenotypic definition of skeletal muscle progenitor cells has not been fully elucidated nor the potential of these cells to differentiate into neurons. Here, we demonstrate that phenotypically homogenous skeletal muscle progenitor cells defined as Lin -CD45-CDII7-CD90+ cells express neural stem cell markers and are responsive to neural induction signals. When exposed to neural induction medium containing basic fibroblast growth factor and brain-derived neurotrophic factor, skeletal muscle progenitor cells dramatically changed their cell morphology, became post-mitotic and began expressing neuronal markers. These results reveal unexpected potentials of muscle progenitor cells and suggest that these cells may potentially be used in cell-based therapies to replace damaged neurons.",
keywords = "Cell-based therapy, Neural differentiation, Progenitor cells, Skeletal muscle",
author = "Takako Kondo and Jamie Case and Edward Srour and Eri Hashino",
year = "2006",
month = "1",
doi = "10.1097/01.wnr.0000192732.00535.ff",
language = "English",
volume = "17",
pages = "1--4",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Skeletal muscle-derived progenitor cells exhibit neural competence

AU - Kondo, Takako

AU - Case, Jamie

AU - Srour, Edward

AU - Hashino, Eri

PY - 2006/1

Y1 - 2006/1

N2 - Skeletal muscle contains heterogenous progenitor cells that give rise to muscle, hematopoietic cells and bone. The exact phenotypic definition of skeletal muscle progenitor cells has not been fully elucidated nor the potential of these cells to differentiate into neurons. Here, we demonstrate that phenotypically homogenous skeletal muscle progenitor cells defined as Lin -CD45-CDII7-CD90+ cells express neural stem cell markers and are responsive to neural induction signals. When exposed to neural induction medium containing basic fibroblast growth factor and brain-derived neurotrophic factor, skeletal muscle progenitor cells dramatically changed their cell morphology, became post-mitotic and began expressing neuronal markers. These results reveal unexpected potentials of muscle progenitor cells and suggest that these cells may potentially be used in cell-based therapies to replace damaged neurons.

AB - Skeletal muscle contains heterogenous progenitor cells that give rise to muscle, hematopoietic cells and bone. The exact phenotypic definition of skeletal muscle progenitor cells has not been fully elucidated nor the potential of these cells to differentiate into neurons. Here, we demonstrate that phenotypically homogenous skeletal muscle progenitor cells defined as Lin -CD45-CDII7-CD90+ cells express neural stem cell markers and are responsive to neural induction signals. When exposed to neural induction medium containing basic fibroblast growth factor and brain-derived neurotrophic factor, skeletal muscle progenitor cells dramatically changed their cell morphology, became post-mitotic and began expressing neuronal markers. These results reveal unexpected potentials of muscle progenitor cells and suggest that these cells may potentially be used in cell-based therapies to replace damaged neurons.

KW - Cell-based therapy

KW - Neural differentiation

KW - Progenitor cells

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=29344465104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=29344465104&partnerID=8YFLogxK

U2 - 10.1097/01.wnr.0000192732.00535.ff

DO - 10.1097/01.wnr.0000192732.00535.ff

M3 - Article

C2 - 16361939

AN - SCOPUS:29344465104

VL - 17

SP - 1

EP - 4

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 1

ER -