Skin fibroblast beta-adrenergic receptor function in manie-depressive illness

Wade H. Berrettini, Josiane Bardakjian, Charles B. Cappellari, Arthur L. Barnett, Allen Albright, John Nurnberger, Elliot S. Gershon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.

Original languageEnglish
Pages (from-to)1439-1443
Number of pages5
JournalBiological Psychiatry
Volume22
Issue number12
DOIs
StatePublished - 1987

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Receptors, Adrenergic, beta
Isoproterenol
Fibroblasts
Skin
Cyclic AMP
Healthy Volunteers

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Berrettini, W. H., Bardakjian, J., Cappellari, C. B., Barnett, A. L., Albright, A., Nurnberger, J., & Gershon, E. S. (1987). Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. Biological Psychiatry, 22(12), 1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6

Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. / Berrettini, Wade H.; Bardakjian, Josiane; Cappellari, Charles B.; Barnett, Arthur L.; Albright, Allen; Nurnberger, John; Gershon, Elliot S.

In: Biological Psychiatry, Vol. 22, No. 12, 1987, p. 1439-1443.

Research output: Contribution to journalArticle

Berrettini, WH, Bardakjian, J, Cappellari, CB, Barnett, AL, Albright, A, Nurnberger, J & Gershon, ES 1987, 'Skin fibroblast beta-adrenergic receptor function in manie-depressive illness', Biological Psychiatry, vol. 22, no. 12, pp. 1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6
Berrettini, Wade H. ; Bardakjian, Josiane ; Cappellari, Charles B. ; Barnett, Arthur L. ; Albright, Allen ; Nurnberger, John ; Gershon, Elliot S. / Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. In: Biological Psychiatry. 1987 ; Vol. 22, No. 12. pp. 1439-1443.
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