Skin fibroblast beta-adrenergic receptor function in manie-depressive illness

Wade H. Berrettini, Josiane Bardakjian, Charles B. Cappellari, Arthur L. Barnett, Allen Albright, John I. Nurnberger, Elliot S. Gershon

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.

Original languageEnglish (US)
Pages (from-to)1439-1443
Number of pages5
JournalBiological psychiatry
Volume22
Issue number12
DOIs
StatePublished - Dec 1987

Fingerprint

Receptors, Adrenergic, beta
Isoproterenol
Fibroblasts
Skin
Cyclic AMP
Healthy Volunteers

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Berrettini, W. H., Bardakjian, J., Cappellari, C. B., Barnett, A. L., Albright, A., Nurnberger, J. I., & Gershon, E. S. (1987). Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. Biological psychiatry, 22(12), 1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6

Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. / Berrettini, Wade H.; Bardakjian, Josiane; Cappellari, Charles B.; Barnett, Arthur L.; Albright, Allen; Nurnberger, John I.; Gershon, Elliot S.

In: Biological psychiatry, Vol. 22, No. 12, 12.1987, p. 1439-1443.

Research output: Contribution to journalArticle

Berrettini, WH, Bardakjian, J, Cappellari, CB, Barnett, AL, Albright, A, Nurnberger, JI & Gershon, ES 1987, 'Skin fibroblast beta-adrenergic receptor function in manie-depressive illness', Biological psychiatry, vol. 22, no. 12, pp. 1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6
Berrettini WH, Bardakjian J, Cappellari CB, Barnett AL, Albright A, Nurnberger JI et al. Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. Biological psychiatry. 1987 Dec;22(12):1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6
Berrettini, Wade H. ; Bardakjian, Josiane ; Cappellari, Charles B. ; Barnett, Arthur L. ; Albright, Allen ; Nurnberger, John I. ; Gershon, Elliot S. / Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. In: Biological psychiatry. 1987 ; Vol. 22, No. 12. pp. 1439-1443.
@article{6472b3cc0c754a00a0419f84fe37a9ab,
title = "Skin fibroblast beta-adrenergic receptor function in manie-depressive illness",
abstract = "Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.",
author = "Berrettini, {Wade H.} and Josiane Bardakjian and Cappellari, {Charles B.} and Barnett, {Arthur L.} and Allen Albright and Nurnberger, {John I.} and Gershon, {Elliot S.}",
year = "1987",
month = "12",
doi = "10.1016/0006-3223(87)90101-6",
language = "English (US)",
volume = "22",
pages = "1439--1443",
journal = "Biological Psychiatry",
issn = "0006-3223",
publisher = "Elsevier USA",
number = "12",

}

TY - JOUR

T1 - Skin fibroblast beta-adrenergic receptor function in manie-depressive illness

AU - Berrettini, Wade H.

AU - Bardakjian, Josiane

AU - Cappellari, Charles B.

AU - Barnett, Arthur L.

AU - Albright, Allen

AU - Nurnberger, John I.

AU - Gershon, Elliot S.

PY - 1987/12

Y1 - 1987/12

N2 - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.

AB - Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.

UR - http://www.scopus.com/inward/record.url?scp=0023637519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023637519&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(87)90101-6

DO - 10.1016/0006-3223(87)90101-6

M3 - Article

C2 - 2823918

AN - SCOPUS:0023637519

VL - 22

SP - 1439

EP - 1443

JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 12

ER -