Skin fibroblast beta-adrenergic receptor function in manie-depressive illness

Wade H. Berrettini, Josiane Bardakjian, Charles B. Cappellari, Arthur L. Barnett, Allen Albright, John I. Nurnberger, Elliot S. Gershon

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.

Original languageEnglish (US)
Pages (from-to)1439-1443
Number of pages5
JournalBiological psychiatry
Volume22
Issue number12
DOIs
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Skin fibroblast beta-adrenergic receptor function in manie-depressive illness'. Together they form a unique fingerprint.

  • Cite this

    Berrettini, W. H., Bardakjian, J., Cappellari, C. B., Barnett, A. L., Albright, A., Nurnberger, J. I., & Gershon, E. S. (1987). Skin fibroblast beta-adrenergic receptor function in manie-depressive illness. Biological psychiatry, 22(12), 1439-1443. https://doi.org/10.1016/0006-3223(87)90101-6