Sleep abnormalities in patients with brain stem lesions

Omkar Markand, Mark L. Dyken

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Seven patients with “locked-in” syndrome were studied by prolonged polygraphic recordings. Severe alterations in the sleep pattern were observed in five patients who had bilateral extensive pontine lesions resulting in tetraplegia, facial and pseudobulbar paralysis, and absence of conjugate horizontal gaze. Rapid eye movement (REM) sleep was entirely absent while non-rapid eye movement (NREM) sleep was absent, reduced, or altered. The remaining two patients, both of whom had relative sparing of horizontal gaze and apparently either no or minimal pontine tegmental involvement, showed both REM and NREM sleep with only a minimal alteration in the sleep pattern. The study suggests that, in human beings as in animals, pontine structures near the midline are essential for control of sleep states.

Original languageEnglish
Pages (from-to)769-776
Number of pages8
JournalNeurology
Volume26
Issue number8
StatePublished - 1976

Fingerprint

Brain Stem
Sleep
Quadriplegia
REM Sleep
Eye Movements
Pseudobulbar Palsy
Animal Structures
Facial Paralysis
Lesion
Alteration

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sleep abnormalities in patients with brain stem lesions. / Markand, Omkar; Dyken, Mark L.

In: Neurology, Vol. 26, No. 8, 1976, p. 769-776.

Research output: Contribution to journalArticle

Markand, O & Dyken, ML 1976, 'Sleep abnormalities in patients with brain stem lesions', Neurology, vol. 26, no. 8, pp. 769-776.
Markand, Omkar ; Dyken, Mark L. / Sleep abnormalities in patients with brain stem lesions. In: Neurology. 1976 ; Vol. 26, No. 8. pp. 769-776.
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