Slow-channel depolarization: mechanism and control of arrhythmias.

J. C. Bailey, V. Elharrar, D. P. Zipes

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The secondary inward current that flows through the slow channel is probably carried primarily by calcium ions. This current is responsible, in part, for the plateau phase of the cardiac action potential. Inward calcium current through the slow channel is essential to excitation-contraction coupling, and enhancement of this current exerts a positive inotropic effect. Transmembrane electrical potentials generated as a consequence of this slow inward current, so-called slow-channel depolarizations or slow responses, have been useful models in recent studies of cardiac autonomic interactions. The significance of the slow response in ventricular arrhythmias remains controversial and awaits more definitive experiments. The role of slow-channel depolarization as a basis for SA and AV nodal electrical activity is suggested by the electrophysiological similarities between these tissues and slow responses produced in vitro. This hypothesis is supported by the responses of these nodal tissues to interventions that augment of impede the slow inward current. More direct evidence in support of this notion may not be obtainable in the near future, since the critical voltage-clamp studies of ionic currents in SA and AV nodes are not technically feasible at this time.

Original languageEnglish
Pages (from-to)417-426
Number of pages10
JournalAnnual Review of Medicine
Volume29
StatePublished - 1978
Externally publishedYes

Fingerprint

Depolarization
Cardiac Arrhythmias
Tissue
Calcium
Excitation Contraction Coupling
Atrioventricular Node
Clamping devices
Membrane Potentials
Action Potentials
Ions
Electric potential
Experiments
In Vitro Techniques

ASJC Scopus subject areas

  • Cell Biology
  • Medicine(all)

Cite this

Bailey, J. C., Elharrar, V., & Zipes, D. P. (1978). Slow-channel depolarization: mechanism and control of arrhythmias. Annual Review of Medicine, 29, 417-426.

Slow-channel depolarization : mechanism and control of arrhythmias. / Bailey, J. C.; Elharrar, V.; Zipes, D. P.

In: Annual Review of Medicine, Vol. 29, 1978, p. 417-426.

Research output: Contribution to journalArticle

Bailey, JC, Elharrar, V & Zipes, DP 1978, 'Slow-channel depolarization: mechanism and control of arrhythmias.', Annual Review of Medicine, vol. 29, pp. 417-426.
Bailey, J. C. ; Elharrar, V. ; Zipes, D. P. / Slow-channel depolarization : mechanism and control of arrhythmias. In: Annual Review of Medicine. 1978 ; Vol. 29. pp. 417-426.
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