Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013

Michael Hawkes, Andrea L. Conroy, Robert O. Opoka, Sophie Namasopo, Kathleen Zhong, W. Conrad Liles, Chandy John, Kevin C. Kain

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

Original languageEnglish (US)
Pages (from-to)1237-1239
Number of pages3
JournalEmerging Infectious Diseases
Volume21
Issue number7
DOIs
StatePublished - 2015
Externally publishedYes

Fingerprint

Uganda
Plasmodium falciparum
Malaria
Single Nucleotide Polymorphism
Parasites
Pediatrics
artemisinine
artesunate

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Epidemiology

Cite this

Hawkes, M., Conroy, A. L., Opoka, R. O., Namasopo, S., Zhong, K., Conrad Liles, W., ... Kain, K. C. (2015). Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013. Emerging Infectious Diseases, 21(7), 1237-1239. https://doi.org/10.3201/eid2107.150213

Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013. / Hawkes, Michael; Conroy, Andrea L.; Opoka, Robert O.; Namasopo, Sophie; Zhong, Kathleen; Conrad Liles, W.; John, Chandy; Kain, Kevin C.

In: Emerging Infectious Diseases, Vol. 21, No. 7, 2015, p. 1237-1239.

Research output: Contribution to journalArticle

Hawkes, M, Conroy, AL, Opoka, RO, Namasopo, S, Zhong, K, Conrad Liles, W, John, C & Kain, KC 2015, 'Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013', Emerging Infectious Diseases, vol. 21, no. 7, pp. 1237-1239. https://doi.org/10.3201/eid2107.150213
Hawkes, Michael ; Conroy, Andrea L. ; Opoka, Robert O. ; Namasopo, Sophie ; Zhong, Kathleen ; Conrad Liles, W. ; John, Chandy ; Kain, Kevin C. / Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013. In: Emerging Infectious Diseases. 2015 ; Vol. 21, No. 7. pp. 1237-1239.
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