Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013

Michael Hawkes, Andrea L. Conroy, Robert O. Opoka, Sophie Namasopo, Kathleen Zhong, W. Conrad Liles, Chandy C. John, Kevin C. Kain

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

Original languageEnglish (US)
Pages (from-to)1237-1239
Number of pages3
JournalEmerging Infectious Diseases
Volume21
Issue number7
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013'. Together they form a unique fingerprint.

  • Cite this

    Hawkes, M., Conroy, A. L., Opoka, R. O., Namasopo, S., Zhong, K., Conrad Liles, W., John, C. C., & Kain, K. C. (2015). Slow clearance of Plasmodium falciparum in severe pediatric malaria, Uganda, 2011–2013. Emerging Infectious Diseases, 21(7), 1237-1239. https://doi.org/10.3201/eid2107.150213