Smad4: Gatekeeper gene in head and neck squamous cell carcinoma

Murray Korc

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-β signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this issue of the JCI, Bornstein and colleagues report that Smad4 expression is decreased in malignant HNSCC and, surprisingly, also in normal-appearing buccal mucosa adjacent to HNSCC (see the related article beginning on page 3408). They also show that targeted conditional deletion of Smad4 in the head and neck epithelium of mice is alone sufficient to initiate spontaneous HNSCC, in conjunction with DNA repair gene dysregulation, genetic instability, and inflammation. These findings point to a novel function for Smad4 as a guardian gene that maintains genomic stability.

Original languageEnglish (US)
Pages (from-to)3208-3212
Number of pages5
JournalJournal of Clinical Investigation
Volume119
Issue number11
DOIs
StatePublished - Nov 2 2009
Externally publishedYes

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Genes
Critical Pathways
Genomic Instability
Mouth Mucosa
Growth
DNA Repair
Carcinogenesis
Neck
Epithelium
Head
Inflammation
Carcinoma, squamous cell of head and neck
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Smad4 : Gatekeeper gene in head and neck squamous cell carcinoma. / Korc, Murray.

In: Journal of Clinical Investigation, Vol. 119, No. 11, 02.11.2009, p. 3208-3212.

Research output: Contribution to journalArticle

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