Small Cell Carcinoma of the bladder associated with schistosomiasis

Miguel Almeida, Rita Canas-Marques, Antonio Lopez-Beltran, Jorge Rebola, Rui Lúcio, Rodolfo Montironi, Liang Cheng, Jorge Fonseca

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Smoking and occupational exposure to bladder cancer carcinogens are the major risk factors for bladder cancer development in industrialized countries, where urothelial carcinoma is the most common histologic type, accounting for > 90% of cases. In Africa and the Middle East, with highly prevalent chronic infection by Schistosoma haematobium (S. haematobium), urinary bladder squamous cell carcinoma is the most prevalent histologic type of bladder cancer, followed by transitional cell carcinoma. Small cell carcinoma accounts for <1% of all primary bladder malignancies. It has the same demographic and clinical features as conventional urothelial carcinoma, and to our knowledge there is no data regarding its association with S. haematobium infection. CASE: We report on the clinicopathological characteristics of a 62-year-old, African man who presented with gross hematuria and advanced disease, resulting in a diagnosis of small cell carcinoma of the bladder associated with S. haematobium infection. He was treated with neoadjuvant chemotherapy followed by cystoprostatectomy, and remains alive after 19 months of follow-up. CONCLUSION: We cannot rule out the possibility that a parasitic infection played a major role in the pathogenesis of small cell bladder carcinoma in this particular case. (Anal Quant Cytopathol Histopathol 2014;36: 339-344).

Original languageEnglish (US)
Pages (from-to)339-344
Number of pages6
JournalAnalytical and Quantitative Cytology and Histology
Volume36
Issue number6
StatePublished - 2014
Externally publishedYes

Fingerprint

Small Cell Carcinoma
Schistosomiasis
Schistosoma haematobium
Urinary Bladder
Urinary Bladder Neoplasms
Infection
Carcinoma
Parasitic Diseases
Middle East
Transitional Cell Carcinoma
Hematuria
Occupational Exposure
Developed Countries
Carcinogens
Squamous Cell Carcinoma
Smoking
Demography
Drug Therapy
Neoplasms

Keywords

  • Bladder cancer
  • Haematobium
  • Prostatectomy
  • Schistosoma small cell carcinoma
  • Squamous cell carcinoma
  • Urinary bladder
  • Urinary bladder cancer

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Medicine(all)

Cite this

Almeida, M., Canas-Marques, R., Lopez-Beltran, A., Rebola, J., Lúcio, R., Montironi, R., ... Fonseca, J. (2014). Small Cell Carcinoma of the bladder associated with schistosomiasis. Analytical and Quantitative Cytology and Histology, 36(6), 339-344.

Small Cell Carcinoma of the bladder associated with schistosomiasis. / Almeida, Miguel; Canas-Marques, Rita; Lopez-Beltran, Antonio; Rebola, Jorge; Lúcio, Rui; Montironi, Rodolfo; Cheng, Liang; Fonseca, Jorge.

In: Analytical and Quantitative Cytology and Histology, Vol. 36, No. 6, 2014, p. 339-344.

Research output: Contribution to journalArticle

Almeida, M, Canas-Marques, R, Lopez-Beltran, A, Rebola, J, Lúcio, R, Montironi, R, Cheng, L & Fonseca, J 2014, 'Small Cell Carcinoma of the bladder associated with schistosomiasis', Analytical and Quantitative Cytology and Histology, vol. 36, no. 6, pp. 339-344.
Almeida M, Canas-Marques R, Lopez-Beltran A, Rebola J, Lúcio R, Montironi R et al. Small Cell Carcinoma of the bladder associated with schistosomiasis. Analytical and Quantitative Cytology and Histology. 2014;36(6):339-344.
Almeida, Miguel ; Canas-Marques, Rita ; Lopez-Beltran, Antonio ; Rebola, Jorge ; Lúcio, Rui ; Montironi, Rodolfo ; Cheng, Liang ; Fonseca, Jorge. / Small Cell Carcinoma of the bladder associated with schistosomiasis. In: Analytical and Quantitative Cytology and Histology. 2014 ; Vol. 36, No. 6. pp. 339-344.
@article{4b616ed761e74df7a485da677609a375,
title = "Small Cell Carcinoma of the bladder associated with schistosomiasis",
abstract = "BACKGROUND: Smoking and occupational exposure to bladder cancer carcinogens are the major risk factors for bladder cancer development in industrialized countries, where urothelial carcinoma is the most common histologic type, accounting for > 90{\%} of cases. In Africa and the Middle East, with highly prevalent chronic infection by Schistosoma haematobium (S. haematobium), urinary bladder squamous cell carcinoma is the most prevalent histologic type of bladder cancer, followed by transitional cell carcinoma. Small cell carcinoma accounts for <1{\%} of all primary bladder malignancies. It has the same demographic and clinical features as conventional urothelial carcinoma, and to our knowledge there is no data regarding its association with S. haematobium infection. CASE: We report on the clinicopathological characteristics of a 62-year-old, African man who presented with gross hematuria and advanced disease, resulting in a diagnosis of small cell carcinoma of the bladder associated with S. haematobium infection. He was treated with neoadjuvant chemotherapy followed by cystoprostatectomy, and remains alive after 19 months of follow-up. CONCLUSION: We cannot rule out the possibility that a parasitic infection played a major role in the pathogenesis of small cell bladder carcinoma in this particular case. (Anal Quant Cytopathol Histopathol 2014;36: 339-344).",
keywords = "Bladder cancer, Haematobium, Prostatectomy, Schistosoma small cell carcinoma, Squamous cell carcinoma, Urinary bladder, Urinary bladder cancer",
author = "Miguel Almeida and Rita Canas-Marques and Antonio Lopez-Beltran and Jorge Rebola and Rui L{\'u}cio and Rodolfo Montironi and Liang Cheng and Jorge Fonseca",
year = "2014",
language = "English (US)",
volume = "36",
pages = "339--344",
journal = "Analytical and Quantitative Cytopathology and Histopathology",
issn = "0301-102X",
publisher = "John Rylands University Library",
number = "6",

}

TY - JOUR

T1 - Small Cell Carcinoma of the bladder associated with schistosomiasis

AU - Almeida, Miguel

AU - Canas-Marques, Rita

AU - Lopez-Beltran, Antonio

AU - Rebola, Jorge

AU - Lúcio, Rui

AU - Montironi, Rodolfo

AU - Cheng, Liang

AU - Fonseca, Jorge

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Smoking and occupational exposure to bladder cancer carcinogens are the major risk factors for bladder cancer development in industrialized countries, where urothelial carcinoma is the most common histologic type, accounting for > 90% of cases. In Africa and the Middle East, with highly prevalent chronic infection by Schistosoma haematobium (S. haematobium), urinary bladder squamous cell carcinoma is the most prevalent histologic type of bladder cancer, followed by transitional cell carcinoma. Small cell carcinoma accounts for <1% of all primary bladder malignancies. It has the same demographic and clinical features as conventional urothelial carcinoma, and to our knowledge there is no data regarding its association with S. haematobium infection. CASE: We report on the clinicopathological characteristics of a 62-year-old, African man who presented with gross hematuria and advanced disease, resulting in a diagnosis of small cell carcinoma of the bladder associated with S. haematobium infection. He was treated with neoadjuvant chemotherapy followed by cystoprostatectomy, and remains alive after 19 months of follow-up. CONCLUSION: We cannot rule out the possibility that a parasitic infection played a major role in the pathogenesis of small cell bladder carcinoma in this particular case. (Anal Quant Cytopathol Histopathol 2014;36: 339-344).

AB - BACKGROUND: Smoking and occupational exposure to bladder cancer carcinogens are the major risk factors for bladder cancer development in industrialized countries, where urothelial carcinoma is the most common histologic type, accounting for > 90% of cases. In Africa and the Middle East, with highly prevalent chronic infection by Schistosoma haematobium (S. haematobium), urinary bladder squamous cell carcinoma is the most prevalent histologic type of bladder cancer, followed by transitional cell carcinoma. Small cell carcinoma accounts for <1% of all primary bladder malignancies. It has the same demographic and clinical features as conventional urothelial carcinoma, and to our knowledge there is no data regarding its association with S. haematobium infection. CASE: We report on the clinicopathological characteristics of a 62-year-old, African man who presented with gross hematuria and advanced disease, resulting in a diagnosis of small cell carcinoma of the bladder associated with S. haematobium infection. He was treated with neoadjuvant chemotherapy followed by cystoprostatectomy, and remains alive after 19 months of follow-up. CONCLUSION: We cannot rule out the possibility that a parasitic infection played a major role in the pathogenesis of small cell bladder carcinoma in this particular case. (Anal Quant Cytopathol Histopathol 2014;36: 339-344).

KW - Bladder cancer

KW - Haematobium

KW - Prostatectomy

KW - Schistosoma small cell carcinoma

KW - Squamous cell carcinoma

KW - Urinary bladder

KW - Urinary bladder cancer

UR - http://www.scopus.com/inward/record.url?scp=84920287427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920287427&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 339

EP - 344

JO - Analytical and Quantitative Cytopathology and Histopathology

JF - Analytical and Quantitative Cytopathology and Histopathology

SN - 0301-102X

IS - 6

ER -