Small cell carcinoma of the prostate: An immunohistochemical study

Jorge L. Yao, Ralph Madeb, Patricia Bourne, Junyi Lei, Ximing Yang, Satish Tickoo, Zhengzhi Liu, Dongfeng Tan, Liang Cheng, Fadi Hatem, Jiaoti Huang, P. Anthony Di Sant'Agnese

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137 Scopus citations

Abstract

Small cell carcinoma of the prostate (SCPC) is morphologically similar to small cell carcinoma of the lung (SCLC) and maybe misinterpreted as Gleason pattern 5b prostate adenocarcinoma (HGPC). Recognition of SCPC is important because of its different clinical behavior. This study aims to characterize the immunophenotype of histologically classic SCPC using a comprehensive panel of markers, to better understand its histogenesis, aid in its classification, and evaluate potential therapeutic targets. Using the World Health Organization morphologic criteria for SCLC, 18 SCPC cases were identified; and studied for the following tumor marker groups: prostate specific/related, neuroendocrine, sex steroid hormone receptors, and prognostic/treatment target-related. Ten cases of UPC were used as controls. PSA was positive in 17% of SCPC and neuroendocrine markers were expressed in HGPC. PSA, TTF-1 and CD56 were the most helpful markers in differentiating between SCPC and HGPC (P<0.01), whereas bombesin/GRP, c-kit, bcl-2, and EGFR expression was more frequent in SCPC. SCPC is best diagnosed by following the World Health Organization diagnostic criteria for SCLC. Immunohistochemical markers can help separate SCPC from HGPC and may be useful in histologically borderline cases. Potential therapeutic targets are identified immunohistochemically in SCPC (Bombesin/GRP, c-kit, bcl-2, and EGFR).

Original languageEnglish (US)
Pages (from-to)705-712
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume30
Issue number6
DOIs
StatePublished - Jun 1 2006

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Keywords

  • Immunohistochemistry
  • Neuroendocrine
  • Prostate
  • Prostatic carcinoma
  • Small cell carcinoma
  • Therapeutic markers

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Yao, J. L., Madeb, R., Bourne, P., Lei, J., Yang, X., Tickoo, S., Liu, Z., Tan, D., Cheng, L., Hatem, F., Huang, J., & Anthony Di Sant'Agnese, P. (2006). Small cell carcinoma of the prostate: An immunohistochemical study. American Journal of Surgical Pathology, 30(6), 705-712. https://doi.org/10.1097/00000478-200606000-00005