Smoking and risk of incident psoriasis among women and men in the United States: A combined analysis

Wenqing Li, Jiali Han, Hyon K. Choi, Abrar A. Qureshi

Research output: Contribution to journalArticle

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Abstract

The authors evaluated the association between smoking and the incidence of psoriasis among 185,836 participants from a cohort of older women (the Nurses' Health Study, 1996-2008), a cohort of younger women (the Nurses' Health Study II, 1991-2005), and a cohort of men (Health Professionals' Follow-up Study, 1986-2006). Information on smoking was collected biennially during follow-up. The authors identified a total of 2,410 participants with incident psoriasis. Compared with never smokers, past smokers had a relative risk of incident psoriasis of 1.39 (95% confidence interval (CI): 1.27, 1.52) and current smokers had a relative risk of 1.94 (95% CI: 1.64, 2.28). For current smokers who smoked 1-14 cigarettes/day, the relative risk was 1.81 (95% CI: 1.38, 2.36); for those who smoked 15-24 cigarettes/day, the relative risk was 2.04 (95% CI: 1.68, 2.47); and for those who smoked 25 or more cigarettes/day, the relative risk was 2.29 (95% CI: 1.74, 3.01). There was a trend toward an increased risk of psoriasis with increasing pack-years or duration of smoking (P trend < 0.0001). The risk was highest among smokers who had 65 or more pack-years of smoking (relative risk = 2.72, 95% CI: 2.05, 3.60) and among those with a smoking duration of 30 or more years (relative risk = 1.99, 95% CI: 1.75, 2.25). The authors observed a graded reduction of risk with an increase in time since smoking cessation (P trend <0.0001). In this study, smoking was found to be an independent risk factor for psoriasis in both women and men. Psoriasis risk was particularly augmented for heavy smokers and persons with longer durations of smoking.

Original languageEnglish (US)
Pages (from-to)402-413
Number of pages12
JournalAmerican Journal of Epidemiology
Volume175
Issue number5
DOIs
StatePublished - Mar 1 2012
Externally publishedYes

Fingerprint

Psoriasis
Smoking
Confidence Intervals
Tobacco Products
Women's Health
Nurses
Men's Health
Smoking Cessation
Risk Reduction Behavior
Incidence

Keywords

  • cohort studies
  • psoriasis
  • smoking

ASJC Scopus subject areas

  • Epidemiology

Cite this

Smoking and risk of incident psoriasis among women and men in the United States : A combined analysis. / Li, Wenqing; Han, Jiali; Choi, Hyon K.; Qureshi, Abrar A.

In: American Journal of Epidemiology, Vol. 175, No. 5, 01.03.2012, p. 402-413.

Research output: Contribution to journalArticle

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