Smoking is underrecognized as a risk factor for chronic pancreatitis

Dhiraj Yadav, Adam Slivka, Stuart Sherman, Robert H. Hawes, Michelle A. Anderson, Frank R. Burton, Randall E. Brand, Michele D. Lewis, Timothy B. Gardner, Andres Gelrud, James Disario, Stephen T. Amann, John Baillie, Christopher Lawrence, Michael O'Connell, Albert B. Lowenfels, Peter A. Banks, David C. Whitcomb

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Background/Aims: Smoking is an established risk factor for chronic pancreatitis (CP). We sought to identify how often and in which CP patients physicians consider smoking to be a risk factor. Methods: We analyzed data on CP patients and controls prospectively enrolled from 19 US centers in the North American Pancreatitis Study-2. We noted each subject's self-reported smoking status and quantified the amount and duration of smoking. We noted whether the enrolling physician (gastroenterologist with specific interest in pancreatology) classified alcohol as the etiology for CP and selected smoking as a risk factor. Results: Among 382/535 (71.4%) CP patients who were self-reported ever smokers, physicians cited smoking as a risk factor in only 173/382 (45.3%). Physicians cited smoking as a risk factor more often among current smokers, when classifying alcohol as CP etiology, and with higher amount and duration of smoking. We observed a wide variability in physician decision to cite smoking as a risk factor. Multivariable regression analysis however confirmed that the association of CP with smoking was independent of physician decision to cite smoking as a risk factor. Conclusions: Physicians often underrecognize smoking as a CP risk factor. Efforts are needed to raise awareness of the association between smoking and CP.

Original languageEnglish (US)
Pages (from-to)713-719
Number of pages7
JournalPancreatology
Volume10
Issue number6
DOIs
StatePublished - Mar 2011

Keywords

  • Alcohol
  • Chronic pancreatitis
  • Risk factor
  • Smoking

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

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    Yadav, D., Slivka, A., Sherman, S., Hawes, R. H., Anderson, M. A., Burton, F. R., Brand, R. E., Lewis, M. D., Gardner, T. B., Gelrud, A., Disario, J., Amann, S. T., Baillie, J., Lawrence, C., O'Connell, M., Lowenfels, A. B., Banks, P. A., & Whitcomb, D. C. (2011). Smoking is underrecognized as a risk factor for chronic pancreatitis. Pancreatology, 10(6), 713-719. https://doi.org/10.1159/000320708