Sodium channel expression in hypothalamic osmosensitive neurons in experimental diabetes

Joshua P. Klein, Matthew J. Craner, Theodore R. Cummins, Joel A. Black, Stephen G. Waxman

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Vasopressin is synthesized by neurons in the supraoptic nucleus of the hypothalamus and its release is controlled by action potentials produced by specific subtypes of voltage-gated sodium channels expressed in these neurons. The hyperosmotic state associated with uncontrolled diabetes mellitus causes elevated levels of plasma vasopressin, which are thought to contribute to the pathologic changes of diabetic nephropathy. We demonstrate here that in the rodent streptozotocin model of diabetes there are increases in expression of mRNA and protein for two sodium channel α-subunits and two β-subunits in the neurons of the supraoptic nucleus. Transient and persistent sodium currents show parallel increases in these diabetic neurons. In the setting of chronic uncontrolled diabetes, these changes in sodium channel expression in the supraoptic nucleus may be maladaptive, contributing to the development of secondary renal complications.

Original languageEnglish (US)
Pages (from-to)1481-1484
Number of pages4
JournalNeuroReport
Volume13
Issue number11
DOIs
StatePublished - Aug 7 2002
Externally publishedYes

Keywords

  • Diabetes
  • Hypothalamus
  • Nephropathy
  • Sodium channel
  • Supraoptic nucleus
  • Vasopressin

ASJC Scopus subject areas

  • Neuroscience(all)

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