Sodium channel expression in NGF-overexpressing transgenic mice

Jenny Fjell, Theodore Cummins, Brian M. Davis, Kathryn M. Albers, Kaj Fried, Stephen G. Waxman, Joel A. Black

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Dorsal root ganglion (DRG) neurons depend on nerve growth factor (NGF) for survival during development, and for the maintenance of phenotypic expression of neuropeptides in the adult. NGF also plays a role in the regulation of expression of functional sodium channels in both PC12 cells and DRG neurons. Transgenic mice that overexpress NGF under the keratin promoter (hyper-NGF mice) show increased levels of NGF in the skin from embryonic day 11 through adulthood, hypertrophy of the peripheral nervous system and mechanical hyperalgesia. We show here that mRNA levels for specific sodium channel isotypes are greater in small (

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalJournal of Neuroscience Research
Volume57
Issue number1
DOIs
StatePublished - Jul 1 1999
Externally publishedYes

Fingerprint

Sodium Channels
Nerve Growth Factor
Transgenic Mice
Spinal Ganglia
Neurons
PC12 Cells
Hyperalgesia
Peripheral Nervous System
Keratins
Neuropeptides
Hypertrophy
Maintenance
Messenger RNA
Skin

Keywords

  • Na6
  • NaG
  • NaN
  • Nerve growth factor
  • PN1
  • Sensory neurons
  • SNS/PN3
  • Sodium channels
  • Sodium currents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Sodium channel expression in NGF-overexpressing transgenic mice. / Fjell, Jenny; Cummins, Theodore; Davis, Brian M.; Albers, Kathryn M.; Fried, Kaj; Waxman, Stephen G.; Black, Joel A.

In: Journal of Neuroscience Research, Vol. 57, No. 1, 01.07.1999, p. 39-47.

Research output: Contribution to journalArticle

Fjell, Jenny ; Cummins, Theodore ; Davis, Brian M. ; Albers, Kathryn M. ; Fried, Kaj ; Waxman, Stephen G. ; Black, Joel A. / Sodium channel expression in NGF-overexpressing transgenic mice. In: Journal of Neuroscience Research. 1999 ; Vol. 57, No. 1. pp. 39-47.
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