Sodium pentosan polysulphate as a polyanionic inhibitor of calcium oxalate crystallization in vitro and in vivo

R. W. Norman, D. S. Scurr, W. G. Robertson, M. Peacock

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Studies in vitro showed that sodium pentosan polysulphate (SPP) is an active inhibitor of calcium oxalate crystal growth and agglomeration and that it acts by increasing the negative zeta potential on the surface of calcium oxalate crystals. Oral administration to human subjects resulted in an increase in the negative zeta potential, which is consistent with an increase in the polyanionic inhibitory activity of urine. SPP may offer a novel approach to the medical management of recurrent calcium oxalate stone disease.

Original languageEnglish (US)
Pages (from-to)369-371
Number of pages3
JournalClinical science
Volume68
Issue number3
DOIs
StatePublished - Jan 1 1985

ASJC Scopus subject areas

  • Medicine(all)

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