Sodium retention in black and white female adolescents in response to salt intake

Cristina Palacios, Karin Wigertz, Berdine R. Martin, Lisa Jackman, J. Howard Pratt, Munro Peacock, George McCabe, Connie M. Weaver

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Increased sodium (Na+) retention in blacks could be related to the high prevalence of hypertension in adult blacks. Na+ retention in response to controlled dietary Na+ has not been rigorously compared in the different race groups. The present study assessed Na+ retention in 22 black and 14 white girls, 11-15 yr old, during 3 wk on a low (1.3 g, 57 mmol)- and during 3 wk on a high (4 g, 172 mmol)-Na+ diet in a randomized order, crossover design. Subjects were matched by postmenarcheal age and weight. After a 1-wk equilibration period, the mean daily Na + retention was 357 ± 69 mg (15.5 ± 3.0 mmol) in blacks and 239 ± 37 mg (10.4 ± 1.6 mmol) in whites on the low-Na + diet and 991 ± 138 mg (43.1 ± 6.0 mmol) in blacks vs. 334 ± 90 mg (14.5 ± 3.9 mmol) in whites (P < 0.001) on the high-Na+ diet. The greater Na+ retention in blacks was not accompanied by an increase in fecal or sweat Na+ excretion. Blood pressure and weight did not increase despite the Na+ retention, and thus, the retained Na+ appeared to reside in a nonextracellular compartment that we speculate to be bone. In summary, black girls showed greater Na+ retention compared with white girls. The difference in Na + handling may contribute to underlying racial differences in susceptibility to hypertension.

Original languageEnglish (US)
Pages (from-to)1858-1863
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number4
DOIs
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Palacios, C., Wigertz, K., Martin, B. R., Jackman, L., Pratt, J. H., Peacock, M., McCabe, G., & Weaver, C. M. (2004). Sodium retention in black and white female adolescents in response to salt intake. Journal of Clinical Endocrinology and Metabolism, 89(4), 1858-1863. https://doi.org/10.1210/jc.2003-031446