Solid organ transplantation for non-TTR hereditary amyloidosis: Report from the 1st International Workshop on the Hereditary Renal Amyloidoses

Arie J. Stangou, Luisa Lobato, Steven Zeldenrust, Mohamed Rela, Bernard Portmann, Reinhold P. Linke, Isabel Conceicao, Gerd Otto, Henryk Wilczek, Ole Suhr, Daniel Azoulay, Gilles Grateau, Maria Picken, John O'Grady, Nigel Heaton, Bo Goran Ericzon, Merrill D. Benson

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Fibrinogen A α-chain (AFib) and apolipoprotein AI (AApoAI) amyloidosis due to variants in the AFib and ApoAI genes are the most common types of hereditary amyloidosis in Europe and the United States. Liver is the exclusive source of the aberrant amyloidogenic protein in AFib and responsible for supplying approximately half of the circulating variant ApoAI. Nephrotic syndrome and renal impairment due to renal amyloidosis are common disease manifestations; however, recent research provides evidence to support a more diverse and systemic disease phenotype, which in turn has implications in the management of the hereditary amyloidoses with solid organ transplantation and, in particular, liver transplantation.

Original languageEnglish (US)
Pages (from-to)81-84
Number of pages4
JournalAmyloid
Volume19
Issue numberSUPPL. 1
DOIs
StatePublished - Jun 2012
Externally publishedYes

Keywords

  • Amyloidosis
  • Apolipoprotein AI
  • Domino
  • Fibrinogen A α-chain
  • Non-TTR
  • Preemptive transplant
  • Transplantation

ASJC Scopus subject areas

  • Internal Medicine

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  • Cite this

    Stangou, A. J., Lobato, L., Zeldenrust, S., Rela, M., Portmann, B., Linke, R. P., Conceicao, I., Otto, G., Wilczek, H., Suhr, O., Azoulay, D., Grateau, G., Picken, M., O'Grady, J., Heaton, N., Ericzon, B. G., & Benson, M. D. (2012). Solid organ transplantation for non-TTR hereditary amyloidosis: Report from the 1st International Workshop on the Hereditary Renal Amyloidoses. Amyloid, 19(SUPPL. 1), 81-84. https://doi.org/10.3109/13506129.2012.668503