Solitary myofibroma in adults

Clinicopathological analysis of a series

A. Beham, Sunil Badve, S. Suster, C. D M Fletcher

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Solitary myofibroma is a recently described, benign neoplasm of superficial soft tissue, which represents the adult counterpart of infantile myofibromatosis and is poorly recognized. Eleven new cases are presented herein. The patients were mostly adults with ages ranging from 13-64 years. They presented with a solitary, usually painless nodule of variable duration in the skin or oral cavity. Histologically, each lesion had a biphasic pattern with spindle cells forming fascicular or whorled areas and rounded, more primitive cells arranged around small vessels, forming haemangiopericytoma-like areas. The characteristic zonation of infantile myofibromatosis was often less marked in adult lesions and there was a haphazard arrangement of the fascicular and pericytic areas in some cases. Hyalinization, especially of the peripheral spindle-celled areas, was frequent. Immunohistochemically, the spindle cells were desmin negative but muscle actin (HHF-35 and IA4) positive. The rounded cells were both desmin and actin negative. Electronmicroscopy confirmed the myofibroblastic/fibroblastic nature of tumour cells in two cases. Although vascular invasion was seen in two cases, solitary adult-type myofibroma pursues a benign clinical course.

Original languageEnglish (US)
Pages (from-to)335-341
Number of pages7
JournalHistopathology
Volume22
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Myofibroma
Desmin
Actins
Hemangiopericytoma
Blood Vessels
Mouth
Neoplasms
Muscles
Skin

Keywords

  • immunohistochemistry
  • myofibroma
  • myofibromatosis
  • skin
  • soft tissue

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Beham, A., Badve, S., Suster, S., & Fletcher, C. D. M. (1993). Solitary myofibroma in adults: Clinicopathological analysis of a series. Histopathology, 22(4), 335-341.

Solitary myofibroma in adults : Clinicopathological analysis of a series. / Beham, A.; Badve, Sunil; Suster, S.; Fletcher, C. D M.

In: Histopathology, Vol. 22, No. 4, 1993, p. 335-341.

Research output: Contribution to journalArticle

Beham, A, Badve, S, Suster, S & Fletcher, CDM 1993, 'Solitary myofibroma in adults: Clinicopathological analysis of a series', Histopathology, vol. 22, no. 4, pp. 335-341.
Beham, A. ; Badve, Sunil ; Suster, S. ; Fletcher, C. D M. / Solitary myofibroma in adults : Clinicopathological analysis of a series. In: Histopathology. 1993 ; Vol. 22, No. 4. pp. 335-341.
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