Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome

Mythily Srinivasan, Krithika N. Kodumudi, Susan Zunt

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Oral lichen planus (OLP) and burning mouth syndrome (BMS) are chronic conditions affecting the oral mucosa characterized by pain and burning sensation. Saliva plays a significant role in the maintenance of physical and functional integrity of normal oral mucosa. Identification of potential "salivary biomarkers" for early diagnosis and/or monitoring of human diseases is being explored. We investigated the soluble forms of innate immune associated proteins CD14 and toll-like receptor-2 in unstimulated whole saliva (UWS) as potential biomarkers for OLP and BMS. Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively. In addition, oral epithelial cells in the saliva of patients with OLP and BMS exhibited elevated levels of CD14 mRNA and decreased levels of TLR-2 mRNA. Interestingly, presence of co-existent oral candidiasis nullified these changes.

Original languageEnglish (US)
Pages (from-to)31-37
Number of pages7
JournalClinical Immunology
Volume126
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Burning Mouth Syndrome
Oral Lichen Planus
Toll-Like Receptor 2
Saliva
Biomarkers
Mouth Mucosa
Oral Candidiasis
Messenger RNA
Early Diagnosis
Epithelial Cells
Maintenance
Pain
Proteins

Keywords

  • Burning mouth syndrome
  • Oral lichen planus
  • Pattern recognition receptor
  • Saliva

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Soluble CD14 and toll-like receptor-2 are potential salivary biomarkers for oral lichen planus and burning mouth syndrome. / Srinivasan, Mythily; Kodumudi, Krithika N.; Zunt, Susan.

In: Clinical Immunology, Vol. 126, No. 1, 01.2008, p. 31-37.

Research output: Contribution to journalArticle

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