Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: A randomized crossover trial

Steven A. Jakeman, Courtney N. Henry, Berdine R. Martin, George P. McCabe, Linda D. McCabe, George S. Jackson, Munro Peacock, Connie M. Weaver

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design:We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare longlived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomizedorder, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P , 0.05) and 7% (P , 0.04), respectively. The bone turnover biomarkers N- Terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. Am J Clin Nutr 2016;104:837-43.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume104
Issue number3
DOIs
StatePublished - Sep 1 2016

Keywords

  • 41CA
  • Bone calcium retention
  • Bone-specific alkaline phosphatase
  • Postmenopausal women
  • Soluble corn fiber

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Jakeman, S. A., Henry, C. N., Martin, B. R., McCabe, G. P., McCabe, L. D., Jackson, G. S., Peacock, M., & Weaver, C. M. (2016). Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: A randomized crossover trial. American Journal of Clinical Nutrition, 104(3), 837-843. https://doi.org/10.3945/ajcn.116.132761