Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: A randomized crossover trial

Steven A. Jakeman, Courtney N. Henry, Berdine R. Martin, George P. McCabe, Linda D. McCabe, George S. Jackson, Munro Peacock, Connie M. Weaver

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design:We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare longlived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomizedorder, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P , 0.05) and 7% (P , 0.04), respectively. The bone turnover biomarkers N- Terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. Am J Clin Nutr 2016;104:837-43.

Original languageEnglish (US)
Pages (from-to)837-843
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume104
Issue number3
DOIs
StatePublished - Sep 1 2016

Fingerprint

Cross-Over Studies
Zea mays
Calcium
Bone and Bones
Urinary Retention
Bone Remodeling
Osteocalcin
Osteogenesis
Radioisotopes
Alkaline Phosphatase
Rodentia
Biomarkers
Technology

Keywords

  • 41CA
  • Bone calcium retention
  • Bone-specific alkaline phosphatase
  • Postmenopausal women
  • Soluble corn fiber

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Medicine(all)
  • Nutrition and Dietetics

Cite this

Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner : A randomized crossover trial. / Jakeman, Steven A.; Henry, Courtney N.; Martin, Berdine R.; McCabe, George P.; McCabe, Linda D.; Jackson, George S.; Peacock, Munro; Weaver, Connie M.

In: American Journal of Clinical Nutrition, Vol. 104, No. 3, 01.09.2016, p. 837-843.

Research output: Contribution to journalArticle

Jakeman, Steven A. ; Henry, Courtney N. ; Martin, Berdine R. ; McCabe, George P. ; McCabe, Linda D. ; Jackson, George S. ; Peacock, Munro ; Weaver, Connie M. / Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner : A randomized crossover trial. In: American Journal of Clinical Nutrition. 2016 ; Vol. 104, No. 3. pp. 837-843.
@article{731fd84541e4422e99899c1ea03a4ec5,
title = "Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: A randomized crossover trial",
abstract = "Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design:We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare longlived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomizedorder, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8{\%} (P , 0.05) and 7{\%} (P , 0.04), respectively. The bone turnover biomarkers N- Terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8{\%}; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. Am J Clin Nutr 2016;104:837-43.",
keywords = "41CA, Bone calcium retention, Bone-specific alkaline phosphatase, Postmenopausal women, Soluble corn fiber",
author = "Jakeman, {Steven A.} and Henry, {Courtney N.} and Martin, {Berdine R.} and McCabe, {George P.} and McCabe, {Linda D.} and Jackson, {George S.} and Munro Peacock and Weaver, {Connie M.}",
year = "2016",
month = "9",
day = "1",
doi = "10.3945/ajcn.116.132761",
language = "English (US)",
volume = "104",
pages = "837--843",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner

T2 - A randomized crossover trial

AU - Jakeman, Steven A.

AU - Henry, Courtney N.

AU - Martin, Berdine R.

AU - McCabe, George P.

AU - McCabe, Linda D.

AU - Jackson, George S.

AU - Peacock, Munro

AU - Weaver, Connie M.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design:We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare longlived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomizedorder, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P , 0.05) and 7% (P , 0.04), respectively. The bone turnover biomarkers N- Terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. Am J Clin Nutr 2016;104:837-43.

AB - Background: Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models. Objective: In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women. Design:We used our novel technology of determining bone calcium retention by following the urinary appearance of 41Ca, a rare longlived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomizedorder, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d. Results: A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P , 0.05) and 7% (P , 0.04), respectively. The bone turnover biomarkers N- Terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). Conclusion: Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d. This study was registered at clinicaltrials.gov as NCT02416947. Am J Clin Nutr 2016;104:837-43.

KW - 41CA

KW - Bone calcium retention

KW - Bone-specific alkaline phosphatase

KW - Postmenopausal women

KW - Soluble corn fiber

UR - http://www.scopus.com/inward/record.url?scp=84985906012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84985906012&partnerID=8YFLogxK

U2 - 10.3945/ajcn.116.132761

DO - 10.3945/ajcn.116.132761

M3 - Article

C2 - 27465372

AN - SCOPUS:84985906012

VL - 104

SP - 837

EP - 843

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -