Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease

L. M. Bekris, M. Khrestian, E. Dyne, Y. Shao, J. Pillai, S. Rao, S. M. Bemiller, Bruce Lamb, H. H. Fernandez, J. B. Leverenz

Research output: Contribution to journalArticle

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Abstract

Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology.

Original languageEnglish (US)
Pages (from-to)19-27
Number of pages9
JournalJournal of Neuroimmunology
Volume319
DOIs
StatePublished - Jun 15 2018

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Myeloid Cells
Neurodegenerative Diseases
Alzheimer Disease
Biomarkers
Inflammation
Blood-Brain Barrier
Innate Immunity
Cell Biology
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Bekris, L. M., Khrestian, M., Dyne, E., Shao, Y., Pillai, J., Rao, S., ... Leverenz, J. B. (2018). Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease. Journal of Neuroimmunology, 319, 19-27. https://doi.org/10.1016/j.jneuroim.2018.03.003

Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease. / Bekris, L. M.; Khrestian, M.; Dyne, E.; Shao, Y.; Pillai, J.; Rao, S.; Bemiller, S. M.; Lamb, Bruce; Fernandez, H. H.; Leverenz, J. B.

In: Journal of Neuroimmunology, Vol. 319, 15.06.2018, p. 19-27.

Research output: Contribution to journalArticle

Bekris, LM, Khrestian, M, Dyne, E, Shao, Y, Pillai, J, Rao, S, Bemiller, SM, Lamb, B, Fernandez, HH & Leverenz, JB 2018, 'Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease', Journal of Neuroimmunology, vol. 319, pp. 19-27. https://doi.org/10.1016/j.jneuroim.2018.03.003
Bekris, L. M. ; Khrestian, M. ; Dyne, E. ; Shao, Y. ; Pillai, J. ; Rao, S. ; Bemiller, S. M. ; Lamb, Bruce ; Fernandez, H. H. ; Leverenz, J. B. / Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease. In: Journal of Neuroimmunology. 2018 ; Vol. 319. pp. 19-27.
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AU - Khrestian, M.

AU - Dyne, E.

AU - Shao, Y.

AU - Pillai, J.

AU - Rao, S.

AU - Bemiller, S. M.

AU - Lamb, Bruce

AU - Fernandez, H. H.

AU - Leverenz, J. B.

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AB - Alzheimer's disease (AD) has been genetically and pathologically associated with neuroinflammation. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial receptor involved in innate immunity. TREM2 rare protein coding genetic variants have been linked to AD. A soluble TREM2 (sTREM2) cleavage product is elevated in AD. It is unclear whether there is a relationship between elevated sTREM2 and markers of inflammation. The hypothesis of this investigation was that central and peripheral inflammation play a role in sTREM2 levels in AD. A consistent association of peripheral or central markers of inflammation and CSF sTREM2 levels was not found, suggesting a limited impact of general inflammation on sTREM2 levels. An association between peripheral sTREM2 levels and CSF sTREM2, as well as an association between CSF sTREM2 and a marker of blood brain barrier integrity, was observed in AD, suggesting a potential role of peripheral TREM2 in central TREM2 biology.

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