Somatic gene therapy into hematopoietic cells: Current status and future implications

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Retroviral-mediated gene transfer is a powerful tool for introducing and expressing single genes into hematopoietic cells. There has clearly been a tremendous amount of progress in the development of retroviral gene transfer technology over the past 7 years. This is evidenced by improvements in transduction efficiency and expression in animals and its selected use currently in human trials. Critical experiments that must yet be performed relate to the in vitro identification, transduction, and expansion of pluripotent hematopoietic stem cells in vitro as well as the development of retroviral vectors that maximize in vivo expression in the desired target cells.

Original languageEnglish (US)
Pages (from-to)155-168
Number of pages14
JournalClinics in Perinatology
Volume20
Issue number1
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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